ArticleScientific reports2022
Scalable mapping of myelin and neuron density in the human brain with micrometer resolution.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Differential Myeloarchitecture of Subfields of the Mammalian Auditory Cortex: A Comparative Approach.Brain, behavior and evolution · 2026Review
- Identification and characterization of the thalamic ventral posterior complex by 11.7T ex vivo diffusion tensor imaging.Brain structure & function · 2025Article
- Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography.Light, science & applications · 2025Article
- Imaging of developing human brains with ex vivo PSOCT and dMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- An open-source replication for fast and accessible light propagation modeling in brain tissue.PloS one · 2025Article
- Segmentation of supragranular and infragranular layers in ultra-high-resolution 7T ex vivo MRI of the human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography.Research square · 2024Article
- Segmentation of supragranular and infragranular layers in ultra-high resolution 7TbioRxiv : the preprint server for biology · 2023Article
- Multi-Scale Label-Free Human Brain Imaging with Integrated Serial Sectioning Polarization Sensitive Optical Coherence Tomography and Two-Photon Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy.Biomedical optics express · 2023Article
- Quantitative optical coherence microscopy of neuron morphology in human entorhinal cortex.Frontiers in neuroscience · 2023Article
- Reconstruction of ovine axonal cytoarchitecture enables more accurate models of brain biomechanics.Communications biology · 2022Article
- Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution.NeuroImage · 2021Article
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Authors and funding
11 authors at 3 institutions in 1 country.
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Abstract
Optical coherence tomography (OCT) is an emerging 3D imaging technique that allows quantification of intrinsic optical properties such as scattering coefficient and back-scattering coefficient, and has proved useful in distinguishing delicate microstructures in the human brain. The origins of scattering in brain tissues are contributed by the myelin content, neuron size and density primarily; however, no quantitative relationships between them have been reported, which hampers the use of OCT in fundamental studies of architectonic areas in the human brain and the pathological evaluations of diseases. Here, we built a generalized linear model based on Mie scattering theory that quantitatively links tissue scattering to myelin content and neuron density in the human brain. We report a strong linear relationship between scattering coefficient and the myelin content that is retained across different regions of the brain. Neuronal cell body turns out to be a secondary contribution to the overall scattering. The optical property of OCT provides a label-free solution for quantifying volumetric myelin content and neuron cells in the human brain.
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