ArticleSleep & breathing = Schlaf & Atmung2022
Mediation effect of hypoxia in the relationship between obstructive sleep apnea and cardiovascular death risk.
Article in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- The impact of continuous positive airway pressure on cardiac mechanics: Findings from a meta-analysis of echocardiographic studies.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP-Intolerant OSA Patients.The Laryngoscope · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to explore the role of hypoxia in the relationship between obstructive sleep apnea (OSA) and cardiovascular disease (CVD) death risk based on data from the Sleep Heart Health Study (SHHS).
methodsMultivariate logistic regression analysis was used to analyze the association between OSA, hypoxia, and CVD death risk. Causal mediation analysis was performed to assess the role of hypoxia. The severity of OSA was evaluated by the apnea-hypopnea index (AHI), and the hypoxia was quantified by the percentage of sleep time with less than 90% oxygen saturation (PCTST90).
resultsOf these 5,145 participants, 989 had no OSA, 2,110 had mild OSA, and 2,046 had moderate-to-severe OSA. After adjusting all confounders, mild OSA [odds ratio (OR): 1.800; 95% confidence interval (CI), 1.192-2.802], moderate-to-severe OSA (OR: 1.745; 95%CI, 1.148-2.758), 0 < PCTST90 < 1 (OR: 1.668; 95%CI, 1.184-2.385), and PCTST90 ≥ 1 (OR: 1.649; 95%CI, 1.148-2.400) were associated with an increased death risk of CVD. Furthermore, participants with mild OSA (OR: 3.742; 95%CI, 3.183-4.398) and moderate-to-severe OSA (OR: 19.671; 95%CI, 16.303-23.734) had a higher risk of hypoxia than those without OSA. Causal mediation analysis indicated that the average direct effect (ADM) of moderate-to-severe OSA and average causal mediation effect (ACME) of hypoxia on CVD death risk were 0.024 (95%CI, 0.004-0.040) and 0.013 (95%CI, 0.005-0.020), respectively, and the average mediating effect ratio was 33.94%.
conclusionHypoxia played a mediating role in the increased death risk of CVD caused by OSA, and the mediating effect of hypoxia did not account for a large proportion.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.