Evidence map›Paper›PMID 35023295›Full record

ArticleESC heart failure2022

Circ_0001206 regulates miR-665/CRKL axis to alleviate hypoxia/reoxygenation-induced cardiomyocyte injury in myocardial infarction.

Dongmei Wang, Limei Tian, Yan Wang, Xiaoli Gao, Hanbo Tang, Junbo Ge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  5. Article
  6. Article
  7. Review
  8. Circular RNAs in organ injury: recent development.Journal of translational medicine · 2022
    Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dongmei WangDepartment of Cardiology, Zhang Ye People's Hospital Affiliated to Hexi University, Zhangye, China.
Limei TianMedical College of Hexi University, Zhangye, China.
Yan WangDepartment of Cardiology, Zhang Ye People's Hospital Affiliated to Hexi University, Zhangye, China.
Xiaoli GaoDepartment of Cardiology, Zhang Ye People's Hospital Affiliated to Hexi University, Zhangye, China.
Hanbo TangDepartment of Cardiac Surgery, Gansu Provincial Maternity and Child-care Hospital, No.143 North Qilihe Street, Lanzhou, Gansu, 730050, China.
Junbo GeDepartment of Cardiac Surgery, Gansu Provincial Maternity and Child-care Hospital, No.143 North Qilihe Street, Lanzhou, Gansu, 730050, China.
Hexi University · CNGansu Provincial Maternal and Child Health Hospital · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsMyocardial infarction (MI) is a type of cardiovascular disease caused by myocardial necrosis. Growing evidences have suggested that circular RNAs (circRNAs) play crucial roles in cardiac hypoxia/reoxygenation (H/R)-induced injury of MI. METHODS AND

resultsHypoxia/reoxygenation model of H9C2 cells was established and circ_0001206 expression was detected via quantitative real-time polymerase chain reaction. Ribonuclease R (RNase R) and Actinomycin D (Act D) assays verified the stability. Cell counting kit-8 (CCK-8), western blot, TUNEL, and flow cytometry assays evaluated cell viability and cell apoptosis. RNA pull-down, RNA binding protein immunoprecipitation (RIP), and luciferase reporter assays explored the mechanisms underlying MI. All experimental data were presented with mean ± standard deviation (SD) and P < 0.05 indicated statistical significance. Circ_0001206 was low-expressed in H9C2 cells under H/R treatment. Circ_0001206 was formed by cyclization of CRK like proto-oncogene, adaptor protein (CRKL). Circ_0001206 overexpression promoted cell viability and inhibited cardiomyocyte apoptosis. It was confirmed that circ_0001206 regulated CRKL expression via acting as a competing endogenous RNA (ceRNA) of microRNA-665 (miR-665). CRKL played a protective role in MI.

conclusionsCirc_0001206 regulates miR-665/CRKL axis to alleviate H/R-induced cardiomyocyte injury in MI. Our findings suggest that circ_0001206 might be a potential target for MI treatment.

Indexed as

MicroRNAsMyocardial InfarctionHumansHypoxiaMyocytes, CardiacRNA, CircularMicroRNAsMIRN665 microRNA, humanRNA, Circularcirc_0001206CRKLmiR-665Myocardial infarction

Identifiers

PMID35023295
PMCPMC8934946
OpenAlexW4206054180

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.