Evidence map›Paper›PMID 35028536›Full record

ArticleiScience2022

Early expansion of CD38+ICOS+ GC Tfh in draining lymph nodes during influenza vaccination immune response.

Hannah Law, Melanie Mach, Annett Howe, Solange Obeid, Brad Milner, Cate Carey, Maxine Elfis, Bertha Fsadni, Katherine Ognenovska, Tri Giang Phan and 6 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Hannah LawThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
Melanie MachThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
Annett HoweThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
Solange ObeidSt Vincent's Hospital Sydney, Sydney 2010, NSW, Australia.
Brad MilnerSt Vincent's Hospital Sydney, Sydney 2010, NSW, Australia.
Cate CareyThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
Maxine ElfisSt Vincent's Hospital Sydney, Sydney 2010, NSW, Australia.
Bertha FsadniSt Vincent's Centre for Applied Medical Research (AMR), Sydney 2010, NSW, Australia.
Katherine OgnenovskaThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
Tri Giang PhanGarvan Institute of Medical Research, Sydney 2010, NSW, Australia.
Diane CareyThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
Yin XuThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
Vanessa VenturiThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
John ZaundersThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
Anthony D KelleherThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
C Mee Ling MunierThe Kirby Institute, UNSW Sydney, Sydney 2052, NSW, Australia.
UNSW Sydney · AUSt Vincent's Hospital Sydney · AUGarvan Institute of Medical Research · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T follicular helper (Tfh) cells provide critical help to B cells during the germinal center (GC) reaction to facilitate generation of protective humoral immunity. Accessing the human lymph node (LN) to study the commitment of CD4 T cells to GC Tfh cell differentiation during

Indexed as

Cell biologyComponents of the immune systemImmune response

Identifiers

PMID35028536
PMCPMC8741621
OpenAlexW4200276009

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.