Evidence map›Paper›PMID 35029322›Full record

ArticleThe FEBS journal2022

Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function.

Tomislav Kokotović, Ewelina M Lenartowicz, Michiel Langeslag, Cosmin I Ciotu, Christopher W Fell, Angelica Scaramuzza, Michael J M Fischer, Michaela Kress, Josef M Penninger, Vanja Nagy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Tomislav KokotovićLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Ewelina M LenartowiczLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Michiel LangeslagDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University of Innsbruck, Austria.
Cosmin I CiotuInstitute of Physiology, Medical University of Vienna, Austria.
Christopher W FellLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Angelica ScaramuzzaLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Michael J M FischerInstitute of Physiology, Medical University of Vienna, Austria.
Michaela KressDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University of Innsbruck, Austria.
Josef M PenningerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, VBC - Vienna BioCenter Campus, Vienna, Austria.
Vanja NagyLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.ORCID 0000-0002-9521-4794
Austrian Academy of Sciences · ATInnsbruck Medical University · ATLudwig Boltzmann Institute for Rare and Undiagnosed Diseases · ATMedical University of Vienna · ATInstitute of Molecular Biotechnology · AT

Funding

Austrian Science Fund FWF P 32924
6 · The paper itself

Abstract

Mesenchyme homeobox protein 2 (MEOX2) is a transcription factor involved in mesoderm differentiation, including development of bones, muscles, vasculature and dermatomes. We have previously identified dysregulation of MEOX2 in fibroblasts from Congenital Insensitivity to Pain patients, and confirmed that btn, the Drosophila homologue of MEOX2, plays a role in nocifensive responses to noxious heat stimuli. To determine the importance of MEOX2 in the mammalian peripheral nervous system, we used a Meox2 heterozygous (Meox2

Indexed as

Homeodomain ProteinsNociceptorsAnimalsGanglia, SpinalHumansMesodermMiceNAV1.7 Voltage-Gated Sodium ChannelNAV1.9 Voltage-Gated Sodium ChannelTranscription FactorsHomeodomain ProteinsMeox2 protein, mouseNAV1.7 Voltage-Gated Sodium ChannelNAV1.9 Voltage-Gated Sodium ChannelScn11a protein, mouseScn9a protein, mouseTranscription Factorsdorsal root gangliaMEOX2Nav1.8nociceptionpain

Identifiers

PMID35029322
PMCPMC9306780
OpenAlexW4205962061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.