Evidence map›Paper›PMID 35033599›Full record

ReviewProgress in neurobiology2022

The omnipresence of autonomic modulation in health and disease.

Julia Forstenpointner, Igor Elman, Roy Freeman, David Borsook

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07529678 (The Effect of Automated Electronic Massage Chair on the Autonomic Nervous System of Female University Student-Athletes and Non- Athletes), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07529678 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effect of Automated Electronic Massage Chair on the Autonomic Nervous System of Female University Student-Athletes and Non- Athletes

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2024 to 2025Enrolled20ConditionsHealthy Young Adults, Physical Activity Levels, Inactive PeopleArmsMassage chair
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Julia ForstenpointnerCenter for Pain and the Brain (Boston Children's Hospital, Massachusetts General Hospital, and McLean Hospital), Harvard Medical School, Boston, MA, USA; Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, SH, Germany. Electronic address: julia.forstenpointner@uksh.de.
Igor ElmanCenter for Pain and the Brain (Boston Children's Hospital, Massachusetts General Hospital, and McLean Hospital), Harvard Medical School, Boston, MA, USA; Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA.
Roy FreemanDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
David BorsookCenter for Pain and the Brain (Boston Children's Hospital, Massachusetts General Hospital, and McLean Hospital), Harvard Medical School, Boston, MA, USA; Departments of Psychiatry and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Center for Pain and the Brain · USBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · US

Funding

The Functional Neuroanatomy of the Human Physiological Stress ResponseR01NS105844 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ADLER, GAIL KURR, BORSOOK, DAVID · 2019 to 2023
$3.7M
NINDS NIH HHS R01 NS105844
6 · The paper itself

Abstract

The Autonomic Nervous System (ANS) is a critical part of the homeostatic machinery with both central and peripheral components. However, little is known about the integration of these components and their joint role in the maintenance of health and in allostatic derailments leading to somatic and/or neuropsychiatric (co)morbidity. Based on a comprehensive literature search on the ANS neuroanatomy we dissect the complex integration of the ANS: (1) First we summarize Stress and Homeostatic Equilibrium - elucidating the responsivity of the ANS to stressors; (2) Second we describe the overall process of how the ANS is involved in Adaptation and Maladaptation to Stress; (3) In the third section the ANS is hierarchically partitioned into the peripheral/spinal, brainstem, subcortical and cortical components of the nervous system. We utilize this anatomical basis to define a model of autonomic integration. (4) Finally, we deploy the model to describe human ANS involvement in (a) Hypofunctional and (b) Hyperfunctional states providing examples in the healthy state and in clinical conditions.

Indexed as

Autonomic Nervous SystemHomeostasisHumansAllostatic loadANSAutonomic nervous systemNeuropsychopathologyParasympatheticSympathetic

Identifiers

PMID35033599
PMCPMC12882736
OpenAlexW4205113833

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.