Evidence map›Paper›PMID 35034646›Full record

Observational studyLipids in health and disease2022

The relationship between Lipocalin-2 level and hepatic steatosis in obese patients with NAFLD after bariatric surgery.

Jiaqi Chen, Shihui Lei, Yueye Huang, Xiaojuan Zha, Lei Gu, Donglei Zhou, Jun Li, Feng Liu, Nannan Li, Lei Du and 4 more

Erratum issuedOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Lipids in health and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jiaqi ChenDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Shihui LeiDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Yueye HuangDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Xiaojuan ZhaDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Lei GuDepartment of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Donglei ZhouDepartment of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Jun LiDepartment of Gastroenterology, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Feng LiuDepartment of Gastroenterology, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Nannan LiDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Lei DuDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Xiu HuangDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Ziwei LinDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China.
Le BuDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China. geyingjun@hotmail.com.
Shen QuDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Clinical Medicine School of Nanjing Medical University, Medicine School of Tongji University, Shanghai, 200072, China. qushencn@hotmail.com.
Tongji University · CNNanjing Medical University · CNShanghai Tenth People's Hospital · CN

Funding

Natural Science Foundation of Shanghai 21ZR1449400
6 · The paper itself

Abstract

backgroundLipocalin-2 (LCN2) has a critical effect on obesity as well as its associated comorbidities. The present study focused on analyzing serum LCN2 levels of obese patients with nonalcoholic fatty liver disease (NAFLD) and on determining relationship of hepatic steatosis improvement with LCN2 levels after laparoscopic sleeve gastrectomy (LSG).

methodsThis work enrolled ninety patients with obesity and NAFLD. Twenty-three of them underwent LSG. Anthropometric and biochemical parameters and serum LCN2 levels were determined at baseline and those at 6-month post-LSG. Controlled attenuation parameter (CAP) measured by FibroScan was adopted for evaluating hepatic steatosis.

resultsAmong severe obesity patients, serum LCN2 levels were significantly increased (111.59 ± 51.16 ng/mL vs. 92.68 ± 32.68 ng/mL, P = 0.035). The CAP value was higher indicating higher liver fat content (360.51 ± 45.14 dB/m vs. 340.78 ± 45.02 dB/m, P = 0.044). With regard to surgical patients, liver function, glucose, and lipid levels were significantly improved after surgery. Serum LCN2 levels significantly decreased (119.74 ± 36.15 ng/mL vs. 87.38 ± 51.65 ng/mL, P = 0.001). Decreased CAP indicated a significant decrease in liver fat content (358.48 ± 46.13 dB/m vs. 260.83 ± 69.64 dB/m, P < 0.001). The decrease in LCN2 levels was significantly related to the reduced hepatic fat content and improvement in steatosis grade after adjusting for gender, age, and BMI decrease.

conclusionsSerum LCN2 levels are related to obesity and NAFLD. The decreased serum LCN2 levels could be an indicator of hepatic steatosis improvement.

Indexed as

AdultBariatric SurgeryBiomarkersFatty LiverFemaleHumansLipocalin-2MaleNon-alcoholic Fatty Liver DiseaseObesity, MorbidRetrospective StudiesBiomarkersLCN2 protein, humanLipocalin-2Hepatic steatosisLaparoscopic sleeve gastrectomyLipocalin-2Nonalcoholic fatty liver disease

Identifiers

PMID35034646
PMCPMC8761269
OpenAlexW4206446573

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.