Evidence map›Paper›PMID 35035666›Full record

ArticleOxidative medicine and cellular longevity2022

Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-

Xiaochu Feng, Xianghang Chen, Muhammad Zaeem, Wanying Zhang, Liwan Song, Lulu Chen, Joana Mubwandarikwa, Xiangxiang Chen, Jian Xiao, Ling Xie and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  3. [Mechanisms of Piezo1-mediated microglial ferroptosis in inhibiting spinal cord injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiaochu FengDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Xianghang ChenDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Muhammad ZaeemDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Wanying ZhangDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Liwan SongDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Lulu ChenDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Joana MubwandarikwaDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Xiangxiang ChenDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Jian XiaoDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.ORCID https://orcid.org/0000-0001-7374-6506
Ling XieDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.ORCID https://orcid.org/0000-0003-2943-3080
Keyong YeDepartment of Orthopaedics, Affiliated Pingyang Hospital and School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.ORCID https://orcid.org/0000-0003-0571-0645
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component of sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if the AMPK/SIRT1/NF-

Indexed as

AMP-Activated Protein KinasesAnimalsAntioxidantsBenzodioxolesDisease Models, AnimalHumansMaleMiceNeuroinflammatory DiseasesNF-kappa BPhenolsSignal TransductionSirtuin 1Spinal Cord InjuriesAMP-Activated Protein KinasesAntioxidantsBenzodioxolesNF-kappa BPhenolssesamolSirtuin 1

Identifiers

PMID35035666
PMCPMC8758308
OpenAlexW4205988167

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.