Evidence map›Paper›PMID 35041297›Full record

ArticlePharmacology research & perspectives2022

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG-018.

David B Finlay, Thuy Nguyen, Thomas F Gamage, Shuli Chen, Daniel G Barrus, Purvi R Patel, Brian F Thomas, Jenny L Wiley, Yanan Zhang, Michelle Glass

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

David B FinlayDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-3160-2931
Thuy NguyenRTI International, Research Triangle Park, North Carolina, USA.
Thomas F GamageRTI International, Research Triangle Park, North Carolina, USA.
Shuli ChenDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Daniel G BarrusRTI International, Research Triangle Park, North Carolina, USA.
Purvi R PatelRTI International, Research Triangle Park, North Carolina, USA.
Brian F ThomasRTI International, Research Triangle Park, North Carolina, USA.
Jenny L WileyRTI International, Research Triangle Park, North Carolina, USA.
Yanan ZhangRTI International, Research Triangle Park, North Carolina, USA.
Michelle GlassDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
RTI International · USUniversity of Otago · NZ

Funding

Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
Allosteric Modulation of the CB1 ReceptorR01DA040693 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI ZHANG, YANAN · 2016 to 2020
$2.4M
In vitro and in vivo characterization of CB1 allosteric modulatorsK01DA045752 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2018 to 2022
$807k
NIDA NIH HHS K01 DA045752NIDA NIH HHS R01 DA040460NIDA NIH HHS R01 DA040693
6 · The paper itself

Abstract

Neutral antagonists of GPCRs remain relatively rare-indeed, a large majority of GPCR antagonists are actually inverse agonists. The synthetic cannabinoid receptor agonist (SCRA) EG-018 was recently reported as a low efficacy cannabinoid receptor agonist. Here we report a comparative characterization of EG-018 and 13 analogues along with extant putative neutral antagonists of CB

Indexed as

Cannabinoid Receptor AgonistsCarbazolesCyclic AMPGTP-Binding ProteinsHEK293 CellsHumansNaphthalenesReceptor, Cannabinoid, CB1Signal TransductionStructure-Activity RelationshipCannabinoid Receptor AgonistsCarbazolesCyclic AMPEG-018GTP-Binding ProteinsNaphthalenesReceptor, Cannabinoid, CB1cannabinoidsCB1 receptorEG-018signal transductionstructure-activity relationships

Identifiers

PMID35041297
PMCPMC8929370
OpenAlexW4206265980

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.