Evidence map›Paper›PMID 35041972›Full record

ArticleJournal of clinical epidemiology2022

SARS-CoV-2 rapid antigen tests provide benefits for epidemic control - observations from Austrian schools.

Jitka Polechová, Kory D Johnson, Pavel Payne, Alex Crozier, Mathias Beiglböck, Pavel Plevka, Eva Schernhammer

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Communicating the Imperfect Diagnostic Accuracy of COVID-19 Rapid Antigen Self-Tests: An Online Randomized Experiment.Medical decision making : an international journal of the Society for Medical Decision Making · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Jitka PolechováFaculty of Mathematics, University of Vienna, Austria. Electronic address: jitka@univie.ac.at.
Kory D JohnsonInstitute of Statistics and Mathematical Methods in Economics, TU Wien, Austria. Electronic address: kory.johnson@tuwien.ac.at.
Pavel PayneCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Alex CrozierDivision of Biosciences, University College London, London, UK.
Mathias BeiglböckFaculty of Mathematics, University of Vienna, Austria.
Pavel PlevkaCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Eva SchernhammerDepartment of Epidemiology, Center for Public Health, Medical University of Vienna, Austria.
Central European Institute of Technology · CZUniversity of Vienna · ATMedical University of Vienna · ATTU Wien · ATUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis paper motivates and justifies the use of antigen tests for epidemic control as distinct from a diagnostic test. STUDY DESIGN AND

settingWe discuss the relative advantages of antigen and PCR tests, summarizing evidence from both the literature as well as Austrian schools, which conducted frequent, mass rapid antigen testing during the spring of 2021. While our report on testing predates Delta, we have updated the review with recent data on viral loads in breakthrough infections and more information about testing efficacy, especially in children.

resultsRapid antigen tests detect proteins at the surface of virus particles, identifying the disease during its infectious phase. In contrast, PCR tests detect viral genomes: they can thus diagnose COVID-19 before the infectious phase but also react to remnants of the virus genome, even weeks after live virus ceases to be detectable in the respiratory tract. Furthermore, the logistics for administering the tests are different. Large-scale rapid antigen testing in Austrian schools showed low false-positive rates along with an approximately 10% lower effective reproduction number in the tested cohort.

conclusionUsing antigen tests at least 2-3 times per week could become a powerful tool to suppress the COVID-19 pandemic.

Indexed as

COVID-19SARS-CoV-2AustriaChildHumansPandemicsSchoolsSensitivity and SpecificityCOVID-19Large-scale testingLateral flow devicePublic healthRepeat testingSARS-CoV-2

Identifiers

PMID35041972
PMCPMC8760838
OpenAlexW4205099522

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.