Evidence mapPaperPMID 35043727Full record

ArticleBioengineered2022

Calcipotriol attenuates liver fibrosis through the inhibition of vitamin D receptor-mediated NF-κB signaling pathway.

Jian Gong, HuanYu Gong, Yang Liu, XinLan Tao, Hao Zhang

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Vitamin DExperimental biology and medicine (Maywood, N.J.) · 2025
    Article
  5. Transcriptomic analysis revealsZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  6. COVID-19 in Children and Vitamin D.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Calcitriol Inhibits NaAsOBiological trace element research · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Pien-Tze-Huang alleviates CClFrontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jian GongDepartment of Infectious Diseases, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.
HuanYu GongDepartment of Infectious Diseases, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.
Yang LiuDepartment of Pathology, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.
XinLan TaoDepartment of Pathology, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.
Hao ZhangDepartment of Nephrology, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver fibrosis is an inevitable stage in the development of chronic liver disease to cirrhosis. Nonetheless, the interventional treatment and achieving control over the disease at this stage can substantially reduce the incidence of liver cirrhosis. To demonstrate these aspects, liver pathological sections of 18 patients with chronic liver disease are collected for research according to the degree of fibrosis. Further, the expressions of related proteins in each group are studied by the Western blot method. The cell proliferation and apoptosis are detected by CKK-8 and flow cytometry analyses. Further, a rat model with carbon tetrachloride (CCl

Indexed as

Liver CirrhosisReceptors, CalcitriolSignal TransductionAnimalsCalcitriolCell LineHumansMaleNF-kappa BRatsRats, Sprague-DawleycalcipotrieneCalcitriolNF-kappa BReceptors, Calcitriolcalcipotriolhepatic stellate cellsliver fibrosisNF-κBVitamin D receptor

Identifiers

PMID35043727
PMCPMC8973618
OpenAlexW4206376772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.