Evidence map›Paper›PMID 35044667›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Raman Microscopy Techniques to Study Lipid Droplet Composition in Cancer Cells.

Mariana C Potcoava, Gregory L Futia, Emily A Gibson, Isabel R Schlaepfer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mariana C PotcoavaDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA. mpotcoav@uic.edu.
Gregory L FutiaDepartment of Bioengineering, University of Colorado Denver, Aurora, CO, USA.
Emily A GibsonDepartment of Bioengineering, University of Colorado Denver, Aurora, CO, USA.
Isabel R SchlaepferDivision of Medical Oncology, Genitourinary Cancer Program, University of Colorado Denver School of Medicine, University of Colorado Denver, Aurora, CO, USA. Isabel.Schlaepfer@CUAnschutz.edu.

Funding

Targeting Lipid Oxidation for Prostate Cancer Imaging and TherapyK01CA168934 · NCI · UNIVERSITY OF COLORADO DENVER · PI SCHLAEPFER, ISABEL RUBIO · 2012 to 2016
$615k
NCI NIH HHS K01 CA168934
6 · The paper itself

Abstract

Raman spectroscopy using feature selection schemes has considerable advantages over gas chromatography for the analysis of fatty acids' composition changes. Here, we introduce an educational methodology to demonstrate the potential of micro-Raman spectroscopy to determine with high accuracy the unsaturation or saturation degrees and composition changes of the fatty acids found in the lipid droplets of the LNCaP prostate cancer cells that were treated with various fatty acids. The methodology uses highly discriminatory wavenumbers among fatty acids present in the sample selected by using the Support Vector Machine algorithm.

Indexed as

Lipid DropletsNeoplasmsFatty AcidsHumansMaleMicroscopySpectrum Analysis, RamanSupport Vector MachineFatty AcidsFatty acidsLipidsNear-infraredNoninvasiveProstate cancerRaman spectroscopySupport vector machine (SVM)

Identifiers

PMID35044667
PMCPMC9939018

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.