Evidence map›Paper›PMID 35045975›Full record

ArticleeNeuro

Mouse Lines with Cre-Mediated Recombination in Retinal Amacrine Cells.

Didem Göz Aytürk, Wenjia You, Constance L Cepko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Flp-recombinase mouse line for genetic manipulation of ipRGCs.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Didem Göz AytürkDepartment of Genetics, Harvard Medical School, Boston, MA 02215.
Wenjia YouDepartment of Genetics, Harvard Medical School, Boston, MA 02215.
Constance L CepkoHoward Hughes Medical Institute, Chevy Chase, MD 20815 cepko@genetics.med.harvard.edu.
Harvard University · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Amacrine cells (ACs) are the most diverse neuronal cell type in the vertebrate retina. Yet little is known about the contribution of ACs to visual processing and retinal disease. A major challenge in evaluating AC function is genetic accessibility. A classic tool of mouse genetics, Cre-mediated recombination, can provide such access. We have screened existing genetically-modified mouse strains and identified multiple candidates that express Cre-recombinase in subsets of retinal ACs. The Cre-expressing mice were crossed to fluorescent-reporter mice to assay Cre expression. In addition, a Cre-dependent fluorescent reporter plasmid was electroporated into the subretinal space of Cre strains. Herein, we report three mouse lines (

Indexed as

Amacrine CellsRetinaAnimalsIntegrasesMiceMice, TransgenicRecombination, GeneticCre recombinaseIntegrasesamacrineCre recombinasefluorescent reporterinhibitory interneuronsmouse geneticsretina

Identifiers

PMID35045975
PMCPMC8856716
OpenAlexW4206108720

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.