Evidence map›Paper›PMID 35050362›Full record

ArticleDiabetes care2022

Associations of Daily Steps and Step Intensity With Incident Diabetes in a Prospective Cohort Study of Older Women: The OPACH Study.

Alexis C Garduno, Andrea Z LaCroix, Michael J LaMonte, David W Dunstan, Kelly R Evenson, Guangxing Wang, Chongzhi Di, Benjamin T Schumacher, John Bellettiere

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Association Between Daily Steps Measured by Accelerometry and Diabetes in ELSA-Brasil Participants.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Alexis C GardunoHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, San Diego, CA.ORCID 0000-0003-4453-8817
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, San Diego, CA.
Michael J LaMonteDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, NY.
David W DunstanBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Kelly R EvensonDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Guangxing WangPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Chongzhi DiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Benjamin T SchumacherHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, San Diego, CA.
John BellettiereHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, San Diego, CA.ORCID 0000-0002-7167-3048
Fred Hutch Cancer Center · USSan Diego State University · USUniversity of California San Diego · USBaker Heart and Diabetes Institute · AUUniversity at Buffalo, State University of New York · USUniversity of North Carolina at Chapel Hill · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortalityP01AG052352 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LACROIX, ANDREA Z. · 2017 to 2022
$9.0M
Objective Physical Activity and Cardiovascular Health in Women Aged 80 and OlderR01HL105065 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LACROIX, ANDREA Z. · 2011 to 2014
$5.0M
Physical Activity, Sedentary Behavior, and Cancer Incidence in WomenR01CA227122 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVENSON, KELLY R. · 2019 to 2022
$2.7M
Novel computational techniques to detect the relationship between sitting patterns and metabolic syndrome in existing cohort studies.R01DK114945 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NATARAJAN, LOKI · 2018 to 2021
$2.6M
Advanced data analytics training for behavioral and social sciences researchT32MH122376 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEKLER, ERIC, POLITIS, DIMITRIS · 2020 to 2024
$1.3M
NCATS NIH HHS UL1 TR001412NCI NIH HHS R01 CA227122NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS R01 HL105065NIA NIH HHS HHSN271201100004CNIA NIH HHS P01 AG052352NIDDK NIH HHS R01 DK114945NIMH NIH HHS T32 MH122376WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

objectiveThe primary aim was to assess associations between total steps per day and incident diabetes, whereas the secondary aim was to assess whether the intensity and/or cadence of steps is associated with incident diabetes. RESEARCH DESIGN AND

methodsWomen without physician-diagnosed diabetes (n = 4,838; mean [SD] age 78.9 [6.7] years) were followed up to 6.9 years; 395 developed diabetes. Hip-worn ActiGraph GT3X+ accelerometers worn for 1 week enabled measures of total, light-intensity, and moderate- to vigorous-intensity (MV-intensity) steps per day. Using Cox proportional hazards analysis we modeled adjusted change in the hazard rate for incident diabetes associated with total, light-intensity, and MV-intensity steps per day. We further estimated the proportion of the steps-diabetes association mediated by BMI.

resultsOn average, participants took 3,729 (SD 2,114) steps/day, of which 1,875 (791) were light-intensity steps and 1,854 ± 1,762 were MV-intensity. More steps per day were associated with a lower hazard rate for incident diabetes. Confounder-adjusted models for a 2,000 steps/day increment yielded hazard ratio (HR) 0.88 (95% CI 0.78-1.00; P = 0.046). After further adjustment for BMI, HR was 0.90 (95% CI 0.80-1.02; P = 0.11). BMI did not significantly mediate the steps-diabetes association (proportion mediated = 17.7% [95% CI -55.0 to 142.0]; P = 0.09]). The relationship between MV-intensity steps per day (HR 0.86 [95% CI 0.74-1.00]; P = 0.04) and incident diabetes was stronger than for light-intensity steps per day (HR 0.97 [95% CI 0.73-1.29]; P = 0.84).

conclusionsThese findings suggest that for older adults, more steps per day are associated with lower incident diabetes and MV-intensity steps are most strongly associated with a lower hazard of diabetes. This evidence supports that regular stepping is an important risk factor for type 2 diabetes prevention in older adults.

Indexed as

Diabetes Mellitus, Type 2AgedFemaleHumansProportional Hazards ModelsProspective StudiesRisk Factors

Identifiers

PMID35050362
PMCPMC8914434
OpenAlexW4205336837

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.