Evidence map›Paper›PMID 35050846›Full record

ArticleAmerican journal of respiratory and critical care medicine2022

Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.

Sadia Haider, Raquel Granell, John Curtin, Sara Fontanella, Alex Cucco, Stephen Turner, Angela Simpson, Graham Roberts, Clare S Murray, John W Holloway and 4 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Genetic characterization of preschool wheeze phenotypes.The Journal of allergy and clinical immunology · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Risk Factors and Mechanisms Leading to Preschool Recurrent Wheeze and Asthma.The journal of allergy and clinical immunology. In practice · 2025
    Review
  8. Article
  9. The impact of child and adolescent health on adult respiratory health: the evidence, gaps and priorities.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  10. Review
  11. Artificial intelligence in pediatric allergy research.European journal of pediatrics · 2024
    Review
  12. Social inequalities in childhood asthma.The World Allergy Organization journal · 2024
    Review
  13. Association of urinary eosinophilic protein X at age 3 years and subsequent persistence of wheezing and asthma diagnosis in adolescence.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Reply to BeckAmerican journal of respiratory and critical care medicine · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Sadia HaiderNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Raquel GranellMedical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
John CurtinDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Sara FontanellaNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Alex CuccoNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Stephen TurnerRoyal Aberdeen Children's Hospital National Health Service Grampian, Aberdeen, United Kingdom.ORCID 0000-0001-8393-5060
Angela SimpsonDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Graham RobertsHuman Development and Health and.ORCID 0000-0003-2252-1248
Clare S MurrayDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
John W HollowayHuman Development and Health and.ORCID 0000-0001-9998-0464
Graham DevereuxClinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Paul CullinanNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Syed Hasan ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Adnan CustovicNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-5218-7071
Imperial College London · GBManchester Academic Health Science Centre · GBUniversity Hospital Southampton NHS Foundation Trust · GBLiverpool School of Tropical Medicine · GBUniversity of Aberdeen · GBUniversity of Bristol · GB

Funding

Medical Research Council G0601361Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MR/K002449/1Medical Research Council MR/L012693/1Medical Research Council MR/S025340/1Wellcome TrustWellcome Trust 108818/15/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AsthmaRespiratory SoundsAdultCadherin Related ProteinsCadherinsHumansInfantLatent Class AnalysisMembrane ProteinsPhenotypeRespiratory Function TestsRisk FactorsCadherin Related ProteinsCadherinsCDHR3 protein, humanMembrane Proteins17q12–21asthmageneticslatent classwheezing phenotypes

Identifiers

PMID35050846
PMCPMC9838626
OpenAlexW4205989980

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.