Evidence map›Paper›PMID 35053372›Full record

ArticleCells2022

Mechanical Compression of Human Airway Epithelial Cells Induces Release of Extracellular Vesicles Containing Tenascin C.

Chimwemwe Mwase, Thien-Khoi N Phung, Michael J O'Sullivan, Jennifer A Mitchel, Margherita De Marzio, Ayşe Kılıç, Scott T Weiss, Jeffrey J Fredberg, Jin-Ah Park

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Compression bioreactor for cultured meat.Current research in food science · 2026
    Article
  3. The dual promise of extracellular vesicles in lung diseases: towards reliable biomarkers and drug delivery vectors.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Deciphering the Tenascin-C Nexus: A Comprehensive Review of Its Involvement in Chronic Respiratory Diseases.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Review
  10. Article
  11. Cell-cell communication: new insights and clinical implications.Signal transduction and targeted therapy · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Extracellular vesicles - on the cusp of a new language in the biological sciences.Extracellular vesicles and circulating nucleic acids · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chimwemwe MwaseDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-0746-2799
Thien-Khoi N PhungDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-1831-3171
Michael J O'SullivanDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jennifer A MitchelDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Margherita De MarzioDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Ayşe KılıçChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Scott T WeissDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jeffrey J FredbergDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-7968-0920
Jin-Ah ParkDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-8930-9287
Harvard University · USBrigham and Women's Hospital · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
Physics of bronchial epithelial unjammingR01HL148152 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J, PARK, JIN-AH · 2019 to 2022
$2.2M
NHLBI NIH HHS R01 HL148152NHLBI NIH HHS T32 HL007118NIDDK NIH HHS P30 DK065988NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

Aberrant remodeling of the asthmatic airway is not well understood but is thought to be attributable in part to mechanical compression of airway epithelial cells. Here, we examine compression-induced expression and secretion of the extracellular matrix protein tenascin C (TNC) from well-differentiated primary human bronchial epithelial (HBE) cells grown in an air-liquid interface culture. We measured

Indexed as

Compressive StrengthStress, MechanicalEpithelial CellsExtracellular VesiclesHumansLungMAP Kinase Signaling SystemReceptors, Transforming Growth Factor betaRNA, MessengerTenascinReceptors, Transforming Growth Factor betaRNA, MessengerTenascinairway epithelial cellsairway remodelingasthmabronchospasmextracellular matrixextracellular vesiclesmechanical compressiontenascin C

Identifiers

PMID35053372
PMCPMC8774246
OpenAlexW4205892845

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.