Evidence map›Paper›PMID 35054780›Full record

ArticleInternational journal of molecular sciences2022

XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks.

Ronald Benjamin, Atoshi Banerjee, Xiaogang Wu, Corey Geurink, Lindsay Buczek, Danielle Eames, Sara G Trimidal, Janice M Pluth, Martin R Schiller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ronald BenjaminNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Atoshi BanerjeeNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.ORCID 0000-0002-3134-1268
Xiaogang WuNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Corey GeurinkNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Lindsay BuczekNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.ORCID 0000-0002-8398-6068
Danielle EamesNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Sara G TrimidalNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Janice M PluthHealth Physics and Diagnostic Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.ORCID 0000-0002-8370-506X
Martin R SchillerNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.ORCID 0000-0003-1671-6823
University of Nevada, Las Vegas · US

Funding

The Genome Analysis and Sequencing Pipeline (GASP)P20GM121325 · NIGMS · UNIVERSITY OF NEVADA LAS VEGAS · PI CHEN, JINGCHUN · 2018 to 2022
$11.5M
HIV Toolbox, an interactive, visual, and customizable HIV Protein OntologyR56AI109156 · NIAID · UNIVERSITY OF NEVADA LAS VEGAS · PI SCHILLER, MARTIN R · 2014 to 2014
$332k
NIAID NIH HHS R56 AI109156NIGMS NIH HHS P20 GM121325NIH HHS AI109156NIH HHS GM121325
6 · The paper itself

Abstract

Double-strand breaks (DSB) are one of the most lethal forms of DNA damage that, if left unrepaired, can lead to genomic instability, cellular transformation, and cell death. In this work, we examined how repair of transcription activator-like effector nuclease (TALEN)-induced DNA damage was altered when knocking out, or inhibiting a function of, two DNA repair proteins, XRCC4 and MRE11, respectively. We developed a fluorescent reporter assay that uses TALENs to introduce DSB and detected repair by the presence of GFP fluorescence. We observed repair of TALEN-induced breaks in the

Indexed as

DNA Breaks, Double-StrandedDNA RepairRNA-SeqDNADNA-Binding ProteinsGene Knockout TechniquesHeLa CellsHumansMRE11 Homologue ProteinTranscription Activator-Like Effector NucleasesDNADNA-Binding ProteinsMRE11 Homologue ProteinMRE11 protein, humanTranscription Activator-Like Effector NucleasesXRCC4 protein, humanDNA repairend joiningmirinNHEJTALENXRCC4

Identifiers

PMID35054780
PMCPMC8776116
OpenAlexW4205491899

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.