Evidence map›Paper›PMID 35054954›Full record

ArticleInternational journal of molecular sciences2022

Searching for New Z-DNA/Z-RNA Binding Proteins Based on Structural Similarity to Experimentally Validated Zα Domain.

Martin Bartas, Kristyna Slychko, Václav Brázda, Jiří Červeň, Christopher A Beaudoin, Tom L Blundell, Petr Pečinka

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Formation and biological implications of Z-DNA.Trends in genetics : TIG · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Functional domain annotation by structural similarity.NAR genomics and bioinformatics · 2024
    Article
  9. Structural and functional characterization ofFrontiers in microbiology · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. AlphaFold2 and its applications in the fields of biology and medicine.Signal transduction and targeted therapy · 2023
    Review
  15. Review
  16. Article
  17. Impacts of Molecular Structure on Nucleic Acid-Protein Interactions.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Martin BartasDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic.ORCID 0000-0002-4415-2220
Kristyna SlychkoDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic.
Václav BrázdaDepartment of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.ORCID 0000-0003-2837-4226
Jiří ČerveňDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic.
Christopher A BeaudoinDepartment of Biochemistry, Sanger Building, University of Cambridge, Tennis Court Rd., Cambridge CB2 1GA, UK.
Tom L BlundellDepartment of Biochemistry, Sanger Building, University of Cambridge, Tennis Court Rd., Cambridge CB2 1GA, UK.ORCID 0000-0002-2708-8992
Petr PečinkaDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic.ORCID 0000-0003-1270-3646
University of Ostrava · CZUniversity of Cambridge · GBCzech Academy of Sciences, Institute of Biophysics · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Z-DNA and Z-RNA are functionally important left-handed structures of nucleic acids, which play a significant role in several molecular and biological processes including DNA replication, gene expression regulation and viral nucleic acid sensing. Most proteins that have been proven to interact with Z-DNA/Z-RNA contain the so-called Zα domain, which is structurally well conserved. To date, only eight proteins with Zα domain have been described within a few organisms (including human, mouse,

Indexed as

Models, MolecularProtein Interaction Domains and MotifsAmino Acid SequenceBinding SitesDNA-Binding ProteinsDNA, Z-FormMolecular Docking SimulationMolecular Dynamics SimulationNucleic Acid ConformationProtein BindingProtein ConformationRNARNA-Binding ProteinsStructure-Activity RelationshipDNA-Binding ProteinsDNA, Z-FormRNARNA-Binding Proteinsbioinformaticsprotein bindingZ-DNAZ-RNAZα domain

Identifiers

PMID35054954
PMCPMC8775963
OpenAlexW4205188039

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.