Evidence map›Paper›PMID 35056136›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in

Ahmed M Alsehli, Sifang Liao, Mohamed H Al-Sabri, Lukas Vasionis, Archana Purohit, Neha Behare, Laura E Clemensson, Michael J Williams, Helgi B Schiöth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 3 countries.

Ahmed M AlsehliDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.
Sifang LiaoDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.
Mohamed H Al-SabriDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.ORCID 0000-0002-9542-8653
Lukas VasionisDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.
Archana PurohitDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.
Neha BehareDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.
Laura E ClemenssonDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.
Michael J WilliamsDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.
Helgi B SchiöthDepartment of Neuroscience, Functional Pharmacology Unit, Uppsala Biomedical Center (BMC), Uppsala University, Husargatan 3, Box 593, 75124 Uppsala, Sweden.
Uppsala University · SE

Funding

Swedish Research Council 2019-01066
6 · The paper itself

Abstract

Statins, HMG Coenzyme A Reductase (HMGCR) inhibitors, are a first-line therapy, used to reduce hypercholesterolemia and the risk for cardiovascular events. While sleep disturbances are recognized as a side-effect of statin treatment, the impact of statins on sleep is under debate. Using Drosophila, we discovered a novel role for Hmgcr in sleep modulation. Loss of pan-neuronal

Indexed as

circadian rhythmcorticotropin releasing factorDH44Drosophilahmgcrinsulinmevalonate pathwaysleepsleep deprivationstatins

Identifiers

PMID35056136
PMCPMC8781969
OpenAlexW4206528216

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.