Evidence map›Paper›PMID 35056413›Full record

ArticleMedicina (Kaunas, Lithuania)2022

Case of Patient with AML with Complex Karyotype including Ultra-Rare t(4;8)(q32;q13), t(4;11)(q21;p15) and Familial Aggregation of Myeloid Malignancies.

Sławomir Milczarek, Ewa Studniak, Bartłomiej Baumert, Michał Janowski, Wioleta Bonda, Joanna Pietrzak, Aleksandra Łanocha, Edyta Paczkowska, Barbara Zdziarska, Bogusław Machaliński

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PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sławomir MilczarekDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0003-4445-6192
Ewa StudniakDepartment of Hematology and Transplantology, Pomeranian Medical University, 71-252 Szczecin, Poland.
Bartłomiej BaumertDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0001-9933-5844
Michał JanowskiDepartment of Hematology and Transplantology, Pomeranian Medical University, 71-252 Szczecin, Poland.ORCID 0000-0003-4656-9318
Wioleta BondaCytogenetic Unit, Independent Public Clinical Hospital nr 2, Pomeranian Medical University, 70-111 Szczecin, Poland.
Joanna PietrzakCytogenetic Unit, Independent Public Clinical Hospital nr 2, Pomeranian Medical University, 70-111 Szczecin, Poland.
Aleksandra ŁanochaDepartment of Hematology and Transplantology, Pomeranian Medical University, 71-252 Szczecin, Poland.
Edyta PaczkowskaDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0001-7052-9741
Barbara ZdziarskaDepartment of Hematology and Transplantology, Pomeranian Medical University, 71-252 Szczecin, Poland.
Bogusław MachalińskiDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Pomeranian Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a unique case of a young woman with acute myeloid leukemia (AML) with complex karyotype. The presence of the t(4;11)(q23;p15) is extremely rare in myeloid leukemias, while t(4;8)(q32;q13) has not yet been described in any leukemia reference. Another interesting issue is the familial aggregation of myeloid malignancies and worse course of the disease in each subsequent generation, as well as an earlier onset of the disease. Our report emphasizes the need for thorough pedigree examination upon myeloid malignancy diagnosis as there are relatives for whom counseling, gene testing, and surveillance may be highly advisable.

Indexed as

Leukemia, Myeloid, AcuteTranslocation, GeneticFemaleHumansKaryotypePedigree11)(q218)(q32AMLfamilial aggregationMPNq13)q15)t(4

Identifiers

PMID35056413
PMCPMC8780170
OpenAlexW4205342355

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.