Evidence map›Paper›PMID 35056739›Full record

ReviewMolecules (Basel, Switzerland)2022

Resveratrol and Immune Cells: A Link to Improve Human Health.

Alessio Alesci, Noemi Nicosia, Angelo Fumia, Federica Giorgianni, Antonello Santini, Nicola Cicero

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Anti-Inflammatory Properties of Resveratrol.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Vaccinomics and adversomics: key elements for a personalized vaccinology.Clinical and experimental vaccine research · 2024
    Review
  15. Article
  16. The Promising Role of Polyphenols in Skin Disorders.Molecules (Basel, Switzerland) · 2024
    Review
  17. Article
  18. Review
  19. Review
  20. Resveratrol againstTropical medicine and infectious disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alessio AlesciDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres, 31, 98166 Messina, Italy.ORCID 0000-0002-7580-8114
Noemi NicosiaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres, 31, 98166 Messina, Italy.ORCID 0000-0002-9453-1237
Angelo FumiaDepartment of Clinical and Experimental Medicine, University of Messina, Padiglione C, A. O. U. Policlinico "G. Martino", Viale Gazzi, 98147 Messina, Italy.
Federica GiorgianniDepartment of Biomedical and Dental Science and Morphofunctional Imaging, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Antonello SantiniDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0001-5505-3327
Nicola CiceroDepartment of Biomedical and Dental Science and Morphofunctional Imaging, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.ORCID 0000-0002-8055-1915
University of Messina · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of polyphenols as adjuvants in lowering risk factors for various debilitating diseases has been investigated in recent years due to their possible antioxidant action. Polyphenols represent a fascinating and relatively new subject of research in nutraceuticals and nutrition, with interest rapidly expanding since they can help maintain health by controlling metabolism, weight, chronic diseases, and cell proliferation. Resveratrol is a phenolic compound found mostly in the pulp, peels, seeds, and stems of red grapes. It has a wide variety of biological actions that can be used to prevent the beginning of various diseases or manage their symptoms. Resveratrol can influence multiple inflammatory and non-inflammatory responses, protecting organs and tissues, thanks to its interaction with immune cells and its activity on SIRT1. This compound has anti-inflammatory, antioxidant, anti-apoptotic, neuroprotective, cardioprotective, anticancer, and antiviral properties, making it a potential adjunct to traditional pharmaceutical therapy in public health. This review aims to provide a comprehensive analysis of resveratrol in terms of active biological effects and mechanism of action in modifying the immune cellular response to promote human psychophysical health.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalAntiviral AgentsCOVID-19 Drug TreatmentDendritic CellsHumansImmunity, CellularMacrophagesMetabolic SyndromeNeuroinflammatory DiseasesResveratrolSirtuin 1Anti-Inflammatory Agents, Non-SteroidalAntiviral AgentsResveratrolSirtuin 1immune cellsinflammationnutraceuticalsresveratrolSIRT1

Identifiers

PMID35056739
PMCPMC8778251
OpenAlexW4206003371

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.