Evidence map›Paper›PMID 35058873›Full record

ReviewFrontiers in neurology2021

Dementia Risk Scores and Their Role in the Implementation of Risk Reduction Guidelines.

Kaarin J Anstey, Lidan Zheng, Ruth Peters, Scherazad Kootar, Mariagnese Barbera, Ruth Stephen, Tarun Dua, Neerja Chowdhary, Alina Solomon, Miia Kivipelto

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Cognitive markers of resilience to dementia in mild Neurocognitive Impairment: a meta- analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  3. Umbrella review and Delphi study on modifiable factors for dementia risk reduction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Pooled it
  4. Trial
  5. Trial
  6. Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 5 countries.

Kaarin J AnsteySchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Lidan ZhengSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Ruth PetersSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Scherazad KootarSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Mariagnese BarberaDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Ruth StephenDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Tarun DuaBrain Health Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland.
Neerja ChowdharyBrain Health Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland.
Alina SolomonDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Miia KivipeltoThe Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Neuroscience Research Australia · AUKarolinska Institutet · SEUniversity of Eastern Finland · FIWorld Health Organization · CH

Funding

World Health Organization 001
6 · The paper itself

Abstract

Dementia prevention is a global health priority. In 2019, the World Health Organisation published its first evidence-based guidelines on dementia risk reduction. We are now at the stage where we need effective tools and resources to assess dementia risk and implement these guidelines into policy and practice. In this paper we review dementia risk scores as a means to facilitate this process. Specifically, we (a) discuss the rationale for dementia risk assessment, (b) outline some conceptual and methodological issues to consider when reviewing risk scores, (c) evaluate some dementia risk scores that are currently in use, and (d) provide some comments about future directions. A dementia risk score is a weighted composite of risk factors that reflects the likelihood of an individual developing dementia. In general, dementia risks scores have a wide range of implementations and benefits including providing early identification of individuals at high risk, improving risk perception for patients and physicians, and helping health professionals recommend targeted interventions to improve lifestyle habits to decrease dementia risk. A number of risk scores for dementia have been published, and some are widely used in research and clinical trials e.g., CAIDE, ANU-ADRI, and LIBRA. However, there are some methodological concerns and limitations associated with the use of these risk scores and more research is needed to increase their effectiveness and applicability. Overall, we conclude that, while further refinement of risk scores is underway, there is adequate evidence to use these assessments to implement guidelines on dementia risk reduction.

Indexed as

cognitive declinedementiarisk assessmentrisk factorsrisk score

Identifiers

PMID35058873
PMCPMC8764151
OpenAlexW4205204142

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.