Evidence map›Paper›PMID 35060315›Full record

ReviewThe FEBS journal2022

Nonrespiratory sites of influenza-associated disease: mechanisms and experimental systems for continued study.

Heather M Froggatt, Nicholas S Heaton

Open access · greenAbstract readReview
In one paragraph

Review in The FEBS journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Deliberating the scientific evidence base for influenza transmission to raw milk consumers.Risk analysis : an official publication of the Society for Risk Analysis · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Microbiology spectrum · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Heather M FroggattDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.
Nicholas S HeatonDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-5307-3428
Duke University · US

Funding

The pathogenic effects of epithelial cells surviving direct influenza virus infectionR01AI137031 · NIAID · DUKE UNIVERSITY · PI Nicholas S Heaton · 2019 to 2026
$4.5M
Loss of cellular identity after influenza virus infection and effects on pulmonary functionR01HL142985 · NHLBI · DUKE UNIVERSITY · PI HEATON, NICHOLAS S · 2018 to 2022
$2.8M
NHLBI NIH HHS R01 HL142985NIAID NIH HHS R01 AI137031
6 · The paper itself

Abstract

The productive replication of human influenza viruses is almost exclusively restricted to cells in the respiratory tract. However, a key aspect of the host response to viral infection is the production of inflammatory cytokines and chemokines that are not similarly tissue restricted. As such, circulating inflammatory mediators, as well as the resulting activated immune cells, can induce damage throughout the body, particularly in individuals with underlying conditions. As a result, more holistic experimental approaches are required to fully understand the pathogenesis and scope of influenza virus-induced disease. This review summarizes what is known about some of the most well-appreciated nonrespiratory tract sites of influenza virus-induced disease, including neurological, cardiovascular, gastrointestinal, muscular and fetal developmental phenotypes. In the context of this discussion, we describe the in vivo experimental systems currently being used to study nonrespiratory symptoms. Finally, we highlight important future questions and potential models that can be used for a more complete understanding of influenza virus-induced disease.

Indexed as

Influenza, HumanOrthomyxoviridae InfectionsCytokinesHumansInflammation MediatorsLungVirus ReplicationCytokinesInflammation Mediatorsanimal modelcardiovascular diseasedisease burdenfetal healthinflammationinfluenza virusmicrobiomemousemuscle wastingneurological disease

Identifiers

PMID35060315
PMCPMC9300775
OpenAlexW4206079206

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.