Evidence map›Paper›PMID 35061071›Full record

ArticleMolecular genetics and genomics : MGG2022

Uniparental markers reveal new insights on subcontinental ancestry and sex-biased admixture in Brazil.

Iriel A Joerin-Luque, Danillo G Augusto, Verónica Calonga-Solís, Rodrigo Coutinho de Almeida, Claudemira Vieira Gusmão Lopes, Maria Luiza Petzl-Erler, Marcia Holsbach Beltrame

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In one paragraph

Article in Molecular genetics and genomics : MGG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iriel A Joerin-LuquePrograma de Pós-Graduação em Genética, Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil. irieljoerin@gmail.com.ORCID http://orcid.org/0000-0003-3683-5547
Danillo G AugustoPrograma de Pós-Graduação em Genética, Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil.ORCID http://orcid.org/0000-0001-5665-8547
Verónica Calonga-SolísPrograma de Pós-Graduação em Genética, Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil.ORCID http://orcid.org/0000-0002-8653-3849
Rodrigo Coutinho de AlmeidaDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-7966-056X
Claudemira Vieira Gusmão LopesCâmara de Educação do Campo, UFPR, Setor Litoral, Matinhos, Paraná, 83260-000, Brazil.ORCID http://orcid.org/0000-0001-5710-5434
Maria Luiza Petzl-ErlerPrograma de Pós-Graduação em Genética, Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil.ORCID http://orcid.org/0000-0002-0345-5276
Marcia Holsbach BeltramePrograma de Pós-Graduação em Genética, Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil.ORCID http://orcid.org/0000-0003-2102-6667

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.067970/2014-01Fundação Araucária PRONEX-FA - Convênio 116/2018 - Protocol 50530
6 · The paper itself

Abstract

The Brazilian population is a product of asymmetric admixture among European men and Amerindian and African women. However, Brazilian subcontinental ancestry is scarcely documented, especially regarding its African roots. Here, we aimed to unveil the uniparental continental and subcontinental contributions from distinct Brazilian regions, including South (n = 43), Southeast (n = 71), the poorly genetically characterized Central-Western region (n = 323), and a subset of unique Brazilian Amerindians (n = 24), in the context of their genome-wide ancestral contributions. The overwhelming majority of European Y haplogroups (85%) contrast sharply with the predominant African and Amerindian mtDNA haplogroups (73.2%) in admixed populations, whereas in Amerindians, non-Native haplogroups could only be detected through the paternal line. Our in-depth investigation of uniparental markers showed signals of an Andean and Central-Brazilian Amerindian maternal contribution to Southeastern and Central-Western Brazil (83.1 ± 2.1% and 56.9 ± 0.2%, respectively), the last having the highest paternal Amerindian ancestry yet described for an admixed Brazilian region (9.7%) and contrasting with higher Southern-Brazilian Amerindian contribution to Southern Brazil (59.6 ± 1%). Unlike the higher African Bantu contribution previously reported for the South and Southeast, a relevant Western African non-Bantu contribution was detected in those regions (85.7 ± 5% and 71.8 ± 10.8% respectively). In contrast, a higher Bantu contribution was described for the first time in the Central-West (64.8 ± 1.3% maternal and 86.9 ± 9.6% paternal). We observed sex-biased signatures consistent with the historically recorded Brazilian colonization and added new insights in the subcontinental maternal ancestry of Brazilians from regions never studied at this level.

Indexed as

Black PeopleDNA, MitochondrialBrazilFemaleGenetics, PopulationHaplotypesHumansMaleDNA, MitochondrialAfrican diasporaHaplotypeMitochondrial lineagesPopulation structureSex-biased gene flowY chromosome

Identifiers

PMID35061071

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.