Evidence map›Paper›PMID 35062872›Full record

Trial reportBMC anesthesiology2022

Combined opioid free and loco-regional anaesthesia enhances the quality of recovery in sleeve gastrectomy done under ERAS protocol: a randomized controlled trial.

Mohamed Ibrahim, Ali M Elnabtity, Ahmed Hegab, Omar A Alnujaidi, Osama El Sanea

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04285255 nacompletednot on this map

Quality of Recovery of Opioid Free Anaesthesia Versus Opioids Anaesthesia Within Enhanced Recovery Protocol Following Laparoscopic Sleeve Gastrectomy in Saudi Arabia, Randomized Controlled Trial

TypeinterventionalSponsorAl Mashfa Medical CenterRan2020 to 2020Enrolled103ConditionsNarcotics, Recovery Quality, Analgesia, Bariatric SurgeryArmsFentanyl, Ketamine, Dexmedetomidine Injection [Precedex], Oblique subcostal transversus abdominis plane block, Lidocaine
NCT05939635 nacompletednot on this mapstarted 2023, after this paper: background citation

Bilateral Ultrasound-guided M-Tapa Block vs External Oblique Intercostal Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Sleeve Gastrectomy Surgery: A Prospective Randomized Controlled Study

TypeinterventionalSponsorOndokuz Mayıs UniversityRan2023 to 2024Enrolled66ConditionsAnesthesia, Regional Anesthesia, Postoperative PainArmsBilateral ultrasound guided external oblique intercostal block (EOIB), Bilateral ultrasound guided Modified thoracoabdominal nerves block through perichondrial approach(M-TAPA) block, IV morphine patient-controlled analgesia (PCA)
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mohamed IbrahimDepartment of Anesthesiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. mibrahim72@hotmail.com.
Ali M ElnabtityDepartment of Anesthesiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed HegabDepartment of Anesthesiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Omar A AlnujaidiAl Mashfa Medical Center, Arraka Shamalia Dist., Khalid Ibn Elwaleed Street, Al Khobar, Kingdom of Saudi Arabia.
Osama El SaneaAl Mashfa Medical Center, Arraka Shamalia Dist., Khalid Ibn Elwaleed Street, Al Khobar, Kingdom of Saudi Arabia.
Zagazig University · EGSaad Specialist Hospital · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is debatable whether opioid-free anaesthesia (OFA) is better suited than multimodal analgesia (MMA) to achieve the goals of enhanced recovery after surgery (ERAS) in patients undergoing laparoscopic sleeve gastrectomy.

methodsIn all patients, anaesthesia was conducted with an i.v. induction with propofol (2 mg. kg-1), myorelaxation with cisatracurium (0.15 mg.kg-1), in addition to an ultrasound-guided bilateral oblique subcostal transverse abdominis plane block. In addition, patients in the OFA group (n = 51) received i.v. dexmedetomidine 0.1 μg.kg-1 and ketamine (0.5 mg. kg-1) at induction, then dexmedetomidine 0.5 μg. kg-1.h-1, ketamine 0.5 mg.kg-1.h-1, and lidocaine 1 mg. kg-1.h-1 for maintenance, while patients in the MMA group (n = 52) had only i.v. fentanyl (1 μg. kg-1) at induction. The primary outcome was the quality of recovery assessed by QoR-40, at the 6th and the 24th postoperative hour. Secondary outcomes were postoperative opioid consumption, time to ambulate, time to tolerate oral fluid, and time to readiness for discharge.

resultsAt the 6th hour, the QoR-40 was higher in the OFA than in the MMA group (respective median [IQR] values: 180 [173-195] vs. 185 [173-191], p < 0.0001), but no longer difference was found at the 24th hour (median values = 191 in both groups). OFA also significantly reduced postoperative pain and morphine consumption (20 mg [1-21] vs. 10 mg [1-11], p = 0.005), as well as time to oral fluid tolerance (238 [151-346] vs. 175 min [98-275], p = 0.022), and readiness for discharge (505 [439-626] vs. 444 min [356-529], p = 0.001), but did not influence time to ambulate.

conclusionWhile regional anaesthesia achieved most of the intraoperative analgesia, avoiding intraoperative opioids with the help of this OFA protocol was able to improve several sensible parameters of postoperative functional recovery, thus improving our knowledge on the OFA effects. CLINICAL TRIAL NUMBER: Registration number NCT04285255.

Indexed as

Enhanced Recovery After SurgeryAdultAnesthesia, ConductionAnesthesia, LocalAnesthetics, DissociativeAnesthetics, IntravenousAnesthetics, LocalAtracuriumDexmedetomidineFemaleFentanylGastrectomyHumansHypnotics and SedativesKetamineLidocaineAnesthetics, DissociativeAnesthetics, IntravenousAnesthetics, LocalAtracuriumcisatracuriumDexmedetomidineFentanylHypnotics and SedativesKetamineLidocaineNeuromuscular Blocking AgentsPropofolMultimodal analgesiaOpioid consumptionOpioid free anaesthesiaQuality of recovery

Identifiers

PMID35062872
PMCPMC8781357
OpenAlexW4207021662

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.