Evidence map›Paper›PMID 35072003›Full record

ArticleiScience2022

Clusterin is involved in mediating the metabolic function of adipose SIRT1.

Pengcheng Zhang, Daniels Konja, Yiwei Zhang, Aimin Xu, In-Kyu Lee, Jae-Han Jeon, Ghader Bashiri, Alok Mitra, Yu Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Pengcheng ZhangThe State Key Laboratory of Pharmaceutical Biotechnology, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Daniels KonjaThe State Key Laboratory of Pharmaceutical Biotechnology, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Yiwei ZhangThe State Key Laboratory of Pharmaceutical Biotechnology, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Aimin XuThe State Key Laboratory of Pharmaceutical Biotechnology, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
In-Kyu LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Daegu41944, South Korea.
Jae-Han JeonDepartment of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Daegu41944, South Korea.
Ghader BashiriSchool of Biological Sciences, University of Auckland, Auckland, New Zealand.
Alok MitraSchool of Biological Sciences, University of Auckland, Auckland, New Zealand.
Yu WangThe State Key Laboratory of Pharmaceutical Biotechnology, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
State Key Laboratory of Pharmaceutical BiotechnologyKyungpook National University Hospital · KRUniversity of Auckland · NZChinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SIRT1 is a metabolic sensor regulating energy homeostasis. The present study revealed that mice with selective overexpression of human SIRT1 in adipose tissue (Adipo-SIRT1) were protected from high-fat diet (HFD)-induced metabolic abnormalities. Adipose SIRT1 was enriched at mitochondria-ER contacts (MERCs) to trigger mitohormesis and unfolded protein response (UPR

Indexed as

Biological sciencesCell biologyMolecular physiology

Identifiers

PMID35072003
PMCPMC8762396
OpenAlexW4200617509

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.