Evidence map›Paper›PMID 35072042›Full record

ArticleKidney medicine2022

Posttransplant Diabetes Mellitus and Immunosuppression Selection in Older and Obese Kidney Recipients.

David A Axelrod, Wisit Cheungpasitporn, Suphamai Bunnapradist, Mark A Schnitzler, Huiling Xiao, Mara McAdams-DeMarco, Yasar Caliskan, Sunjae Bae, JiYoon B Ahn, Dorry L Segev and 3 more

Open access · goldAbstract read
In one paragraph

Article in Kidney medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  10. Early steroid withdrawal and kidney transplant outcomes in first-transplant and retransplant recipients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

David A AxelrodUniversity of Iowa, Iowa City, Iowa.
Wisit CheungpasitpornMayo Clinic, Rochester, Minnesota.
Suphamai BunnapradistUniversity of California Los Angeles, Los Angeles, California.
Mark A SchnitzlerSaint Louis University Center for Abdominal Transplantation, Saint Louis, Missouri.
Huiling XiaoSaint Louis University Center for Abdominal Transplantation, Saint Louis, Missouri.
Mara McAdams-DeMarcoJohns Hopkins School of Medicine, Baltimore, Maryland.
Yasar CaliskanSaint Louis University Center for Abdominal Transplantation, Saint Louis, Missouri.
Sunjae BaeJohns Hopkins School of Medicine, Baltimore, Maryland.
JiYoon B AhnJohns Hopkins School of Medicine, Baltimore, Maryland.
Dorry L SegevJohns Hopkins School of Medicine, Baltimore, Maryland.
Ngan N LamUniversity of Calgary, Calgary, Canada.
Gregory P HessDrexel University, Philadelphia, Pennsylvania.
Krista L LentineUniversity of Iowa, Iowa City, Iowa.
Johns Hopkins University · USSaint Louis University · USUniversity of Iowa · USDrexel University · USMayo Clinic · USUniversity of Calgary · CAUniversity of California, Los Angeles · US

Funding

Developing personalized immunosuppression for older kidney transplant recipientsR01DK120518 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2019 to 2022
$2.7M
NIDDK NIH HHS R01 DK120518
6 · The paper itself

Abstract

RATIONALE &

objectivePosttransplant diabetes mellitus (DM) after kidney transplantation increases morbidity and mortality, particularly in older and obese recipients. We aimed to examine the impact of immunosuppression selection on the risk of posttransplant DM among both older and obese kidney transplant recipients. STUDY

designRetrospective database study. SETTING &

participantsKidney-only transplant recipients aged ≥18 years from 2005 to 2016 in the United States from US Renal Data System records, which integrate Organ Procurement and Transplantation Network/United Network for Organ Sharing records with Medicare billing claims. EXPOSURES: Various immunosuppression regimens in the first 3 months after transplant. OUTCOMES: Development of DM >3 months-to-1 year posttransplant. ANALYTICAL APPROACH: We used multivariable Cox regression to compare the incidence of posttransplant DM by immunosuppression regimen with the reference regimen of thymoglobulin (TMG) or alemtuzumab (ALEM) with tacrolimus + mycophenolic acid + prednisone using inverse propensity weighting.

results12.7% of kidney transplant recipients developed posttransplant DM with higher incidences in older (≥55 years vs <55 years: 16.7% vs 10.1%) and obese (body mass index [BMI] ≥ 30 kg/m LIMITATIONS: Retrospective study and lacked data on immunosuppression levels.

conclusionsThe beneficial impact of steroid avoidance using tacrolimus on posttransplant DM appears to differ by patient age and induction regimen.

Indexed as

Immunosuppressionkidney transplantationnew onset diabetes after transplantationposttransplant diabetes mellitustransplantation

Identifiers

PMID35072042
PMCPMC8767140
OpenAlexW3209981470

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.