Evidence map›Paper›PMID 35072089›Full record

ArticleAmerican journal of biomedical science & research2022

Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States.

N Tran, T Garcia, M Aniqa, S Ali, A Ally, S M Nauli

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of biomedical science & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 5 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 5 syntheses or guidelines pooled it, 145 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. General View of Arachidonic Acid (AA) Metabolism.Reviews of physiology, biochemistry and pharmacology · 2027
    Review
  8. Article
  9. Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
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  20. Article

139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

N TranArkansas College of Osteopathic Medicine, Fort Smith, AR, USA.
T GarciaArkansas College of Osteopathic Medicine, Fort Smith, AR, USA.
M AniqaArkansas College of Osteopathic Medicine, Fort Smith, AR, USA.
S AliArkansas College of Osteopathic Medicine, Fort Smith, AR, USA.
A AllyArkansas College of Osteopathic Medicine, Fort Smith, AR, USA.
S M NauliChapman University and University of California, Irvine, CA, USA.
University of Arkansas – Fort Smith · USChapman University · US

Funding

The roles of neuronal primary cilia in Alzheimer's diseaseR01HL147311 · NHLBI · CHAPMAN UNIVERSITY · PI NAULI, SURYA · 2020 to 2023
$2.1M
NHLBI NIH HHS R01 HL147311
6 · The paper itself

Abstract

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a healthy cardiovascular system. The importance of eNOS can be emphasized from the genetic polymorphisms of the eNOS gene, uncoupling of eNOS dimerization, and its numerous signaling regulations. The activity of eNOS on the cardiac myocytes, vasculature, and the central nervous system are discussed. The effects of eNOS on the sympathetic autonomic nervous system (SANS) and the parasympathetic autonomic nervous system (PANS), both of which profoundly influence the cardiovascular system, will be elaborated. The relationship between the eNOS protein with cardiovascular autonomic reflexes such as the baroreflex and the

Indexed as

AngiotensinArteriosclerosisBaroreflexBlood PressureCardiovascular ReflexCyclic GMPEndotheliumENOS DimerizationENOS geneENOS polymorphismExercise Pressor ReflexGlutamateHypertensionMyocardial InfarctionNitric OxideNociceptionStrokeSympa-thetic Nervous SystemVasodilatationVentrolateral Medulla

Identifiers

PMID35072089
PMCPMC8774925
OpenAlexW4207093158

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.