ArticleAmerican journal of respiratory and critical care medicine2022
Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension.
Open access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
12.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Prognostic Value of Serial Risk Stratification in Adult and Pediatric Pulmonary Arterial Hypertension: A Systematic Review.Journal of the American Heart Association · 2024Pooled it
- Risk stratification in adult and pediatric pulmonary arterial hypertension: A systematic review.Frontiers in cardiovascular medicine · 2022Pooled it
- Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex-Differential Proteins and Candidate Therapeutic Targets.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Artificial Intelligence and Multi-Omics Approaches in the Precision Management of Pulmonary Hypertension: From Early Diagnosis to Therapeutic Stratification.International journal of molecular sciences · 2026Review
- Inflammation and Obesity Correlate in Pulmonary Hypertension but Are Associated with Diverging Outcomes.American journal of respiratory and critical care medicine · 2026Article
- The NOTCH3 extracellular domain is a serum biomarker for pulmonary arterial hypertension.Nature medicine · 2026Article
- Endoglin as a BMP9 co-receptor in vascular endothelial cells: prodomain displacement and TGFBRII recruitment.Nature communications · 2025Article
- Protein biomarkers in pulmonary arterial hypertension: advances, clinical relevance, and translational challenges.Journal of translational medicine · 2025Review
- SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH.Scientific reports · 2025Article
- Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension.Circulation. Genomic and precision medicine · 2025Article
- Clustering Patients with Pulmonary Hypertension Using the Plasma Proteome.American journal of respiratory and critical care medicine · 2025Article
- Cluster analysis identifies quantitative CT imaging-based subgroups in COPD subjects with pulmonary artery enlargement.The European respiratory journal · 2025Article
- Lipid Ratios for Diagnosis and Prognosis of Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2025Article
- Predicting Response to Switching From Phosphodiesterase Type 5 Inhibitor to Riociguat in Patients With Pulmonary Arterial Hypertension: Biomarker and Responder Analysis of the RESPITE and REPLACE Studies.Pulmonary circulation · 2025Article
- Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape.Expert opinion on therapeutic targets · 2025Review
- Management of Pulmonary Arterial Hypertension: Current Strategies and Future Prospects.Life (Basel, Switzerland) · 2025Review
- Deep plasma and tissue proteome profiling of knockout mice reveals pathways associated withJournal of molecular and cellular cardiology plus · 2025Article
- Mechanisms and treatment of pulmonary arterial hypertension.Nature reviews. Cardiology · 2025Review
- Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension.JHLT open · 2025Article
- Plasma SVEP1 Levels Predict Cardiovascular Events in Hypertrophic Cardiomyopathy Beyond Conventional Clinical Risk Models Including NT-proBNP.Circulation. Heart failure · 2025Article
Corrections and comments
- Commented on by
Authors and funding
22 authors at 9 institutions in 2 countries.
Christopher J RhodesNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0002-4962-3204
John WhartonNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-8110-2575
Emilia M SwietlikDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Lars HarbaumNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0002-9422-6195
Barbara GirerdUniversité Paris-Saclay, AP-HP, INSERM UMR_S 999, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
J Gerry CoghlanDepartment of Cardiology, Royal Free Campus, University College London, London, United Kingdom.
James LordanUniversity of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.
Colin ChurchUniversity of Glasgow, Glasgow, Scotland, United Kingdom.
Joanna Pepke-ZabaPulmonary Vascular Disease Unit, Royal Papworth Hospital, Cambridge, United Kingdom.
Mark ToshnerDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Stephen J WortNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
David G KielyDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
Robin CondliffeDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
Allan LawrieDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.ORCID 0000-0003-4192-9505
Stefan GräfDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-1315-8873
David MontaniUniversité Paris-Saclay, AP-HP, INSERM UMR_S 999, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.ORCID 0000-0002-9358-6922
Athénaïs BouclyUniversité Paris-Saclay, AP-HP, INSERM UMR_S 999, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.ORCID 0000-0001-6246-5557
Olivier SitbonUniversité Paris-Saclay, AP-HP, INSERM UMR_S 999, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Marc HumbertUniversité Paris-Saclay, AP-HP, INSERM UMR_S 999, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.ORCID 0000-0003-0703-2892
Luke S HowardNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Nicholas W MorrellDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Martin R WilkinsNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0003-3926-1171
Imperial College London · GBInserm · FRUniversity of Cambridge · GBRoyal Hallamshire Hospital · GBNewcastle University · GBPapworth Hospital · GBThe Royal Free Hospital · GBUniversity of Glasgow · GBUniversity of Sheffield · GB
Funding
British Heart Foundation CH/09/001/25945British Heart Foundation FS/13/48/30453British Heart Foundation FS/15/59/31839British Heart Foundation FS/18/52/33808British Heart Foundation RE/18/4/34215British Heart Foundation SP/12/12/29836British Heart Foundation SP/18/10/33975Department of HealthMedical Research Council MR/K020919/1
Abstract
PubMed holds no abstract for this paper.
Indexed as
Pulmonary Arterial HypertensionArea Under CurveBiomarkersFamilial Primary Pulmonary HypertensionHumansNatriuretic Peptide, BrainPeptide FragmentsPrognosisProteomeBiomarkersNatriuretic Peptide, BrainPeptide FragmentsProteomebiomarkersclinical outcomesprognosis
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.