Evidence map›Paper›PMID 35083015›Full record

ArticleIranian journal of basic medical sciences2021

GABAergic neurons in the nucleus accumbens regulate hedonic food intake via orexin-A expression in the lateral hypothalamus.

Jieting Kong, Shengli Gao, Xiaoman He, Nana Zhang, Jinfang Huang, Pengfei Ji, Shouheng Yao, Xiang Ren, Yiru Wang, Yanling Gong and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jieting KongDepartment of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China.
Shengli GaoDepartment of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, China.
Xiaoman HeDepartment of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China.
Nana ZhangDepartment of Clinical Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China.
Jinfang HuangDepartment of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China.
Pengfei JiQingdao Medical College, Qingdao University, Qingdao, China.
Shouheng YaoQingdao Medical College, Qingdao University, Qingdao, China.
Xiang RenQingdao Medical College, Qingdao University, Qingdao, China.
Yiru WangQingdao Medical College, Qingdao University, Qingdao, China.
Yanling GongDepartment of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China.
Feifei GuoDepartment of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China.
Qingdao University · CNAffiliated Hospital of Qingdao University · CNQingdao University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the regulatory effects of the nucleus accumbens (NAcSh)-lateral hypothalamus (LHA) GABAergic neural pathway on palatable food (PF) intake via orexin-A expression in diet-induced obesity (DIO) rats. MATERIALS AND

methodsNAcSh-LHA GABAergic pathways were observed by fluorogold retrograde tracing combined with fluorescence immunohistochemistry, and the regulatory effects of this neural pathway on PF intake were detected after 1) microinjection of GABA-A receptor agonist muscimol (MUS) or antagonist bicuculine (BIC) into LHA, 2) electrical stimulation NAcSh, and 3) blocking the orexin-A receptor by icv SB334867.

resultsCompared with rats on a normal diet (ND), NAcSh-LHA GABAergic neurons in the DIO rats were significantly decreased, and orexin-A expression in LHA significantly increased (

conclusionThis GABAergic pathway could regulate the expression of orexin-A in LHA and PF intake. Orexin-A neurons in LHA of DIO rats might be less sensitive to GABAergic signals and may consequently lead to more hedonic food intake.

Indexed as

Food intakeGABANucleus accumbensObesityOrexin-A

Identifiers

PMID35083015
PMCPMC8751738
OpenAlexW3196492544

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.