ReviewAnnual review of medicine2022
Spectrum of Phenotypes and Causes of Type 2 Diabetes in Children.
Review in Annual review of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy and safety of glucose-lowering drugs in children and adolescents with type 2 diabetes: A systematic review and network meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Growth Hormone Mediators and Glycemic Control in Youths With Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2024Trial
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Prevalence, incidence, and risk factors of diabetic retinopathy and macular edema in patients with early and late-onset type 2 diabetes mellitus.Journal of diabetes investigation · 2025Article
- Trends in the incidence of young-adult-onset diabetes by diabetes type: a multi-national population-based study from an international diabetes consortium.The lancet. Diabetes & endocrinology · 2024Article
- SARS-CoV-2 Infection and New-Onset Type 2 Diabetes Among Pediatric Patients, 2020 to 2022.JAMA network open · 2024Article
- Youth-onset Type 2 Diabetes: An Overview of Pathophysiology, Prognosis, Prevention and Management.Current diabetes reports · 2024Review
- Non-Pharmacological Treatment for Cardiovascular Risk Prevention in Children and Adolescents with Obesity.Nutrients · 2024Review
- Type 2 diabetes in children and adolescents: Exploring the disease heterogeneity and research gaps to optimum management.World journal of clinical pediatrics · 2024Review
- Challenges and pitfalls of youth-onset type 2 diabetes.World journal of diabetes · 2024Review
- Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications.Scientific reports · 2024Article
- Diabetes Study of Children of Diverse Ethnicity and Race: Study design.Diabetes/metabolism research and reviews · 2024Observational
- Morin Ameliorates Myocardial Injury in Diabetic Rats via Modulation of Autophagy, Apoptosis, Inflammation, and Oxidative Stress.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Use of Continuous Glucose Monitors by People Without Diabetes: An Idea Whose Time Has Come?Journal of diabetes science and technology · 2023Article
- Astragaloside IV-mediated inhibition of oxidative stress by upregulation of ghrelin in type 2 diabetes-induced cognitive impairment.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Rapid Decline in β-Cell Function and Increasing Adiposity Are Associated With Conversion to Type 2 Diabetes in At-Risk Latino Youth.Diabetes · 2023Article
- Imprecise Diagnosis of Diabetes Type in Youth: Prevalence, Characteristics, and Implications.Research square · 2023Article
- Glucagon-like Peptide-1 Receptor Agonists for the Treatment of Type 2 Diabetes in Youth.TouchREVIEWS in endocrinology · 2023Review
- Youth-Onset Type 2 Diabetes: Burden of Complications and Socioeconomic Cost.Current diabetes reports · 2023Review
- Transitioning care in youth-onset type 1 and type 2 diabetes: a scoping review protocol using the socio-ecological model framework.BMJ open · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Several factors, including genetics, family history, diet, physical activity, obesity, and insulin resistance in puberty, appear to increase the risk of type 2 diabetes in youth. Youth-onset type 2 diabetes is often thought of as a single entity but rather exists as a spectrum of disease with differences in presentation, metabolic characteristics, clinical progression, and complication rates. We review what is currently known regarding the risks associated with developing type 2 diabetes in youth. Additionally, we focus on the spectrum of phenotypes of pediatric type 2 diabetes, discuss the pathogenic underpinnings and potential therapeutic relevance of this heterogeneity, and compare youth-onset type 2 diabetes with type 1 diabetes and adult-onset type 2 diabetes. Finally, we highlight knowledge gaps in prediction and prevention of youth-onset type 2 diabetes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.