ReviewCurrent opinion in neurology2022
Sudden unexpected death in epilepsy.
Review in Current opinion in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Molecular mechanisms of sudden unexplained death and recent updates on molecular autopsy strategies for forensic investigation.International journal of legal medicine · 2026Review
- Economic burden and cost determinants of epilepsy in Georgia: A longitudinal cost-of-illness study.Epilepsia open · 2026Article
- Cardiac effects of one-year levetiracetam monotherapy in children with genetic generalized epilepsy: a prospective longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Pathophysiological frameworks and emerging preventative strategies in SUDEP.Frontiers in neurology · 2026Review
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- The thalamus: Structure, function, and neurotherapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Mortality of Epilepsy in Chinese Populations: A Comprehensive Review.Neuroepidemiology · 2025Review
- A novel wearable device for automated real-time detection of epileptic seizures.BMC biomedical engineering · 2023Article
- Review
- Noradrenergic pathway from the locus coeruleus to heart is implicated in modulating SUDEP.iScience · 2023Article
- Review
- Implementation of a Morphological Filter for Removing Spikes from the Epileptic Brain Signals to Improve Identification Ripples.Sensors (Basel, Switzerland) · 2022Article
- Article
- Diagnosing epileptic seizures using combined features from independent components and prediction probability from EEG data.Digital healthArticle
- Real-World Practices in Educating Patients and Caregivers About Sudden Unexpected Death in Epilepsy: A Scoping Review.Saudi journal of medicine & medical sciencesReview
- ABCDEF…SUDEP: Action Potential Barrage in (Superior) Colliculus Causes (Spreading) Depolarization Leading to Epilepsy Fatality.Epilepsy currentsArticle
- Imaging Sphingosine-1-Phosphate Receptor: A Promising Strategy to Neuroinflammation of Epilepsy.Molecular imagingReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewSudden unexpected death in epilepsy (SUDEP) is a major contributor to premature mortality in people with epilepsy. This review provides an update on recent findings on the epidemiology of SUDEP, clinical risk factors and potential mechanisms. RECENT
findingsThe overall risk rate of SUDEP is approximately 1 per 1000 patients per year in the general epilepsy population and that children and older adults have a similar incidence. Generalized convulsive seizures (GCS), perhaps through their effects on brainstem cardiopulmonary networks, can cause significant postictal respiratory and autonomic dysfunction though other mechanisms likely exist as well. Work in animal models of SUDEP has identified multiple neurotransmitter systems, which may be future targets for pharmacological intervention. There are also chronic functional and structural changes in autonomic function in patients who subsequently die from SUDEP suggesting that some SUDEP risk is dynamic. Modifiable risks for SUDEP include GCS seizure frequency, medication adherence and nighttime supervision. SUMMARY: Current knowledge of SUDEP risk factors has identified multiple targets for SUDEP prevention today as we await more specific therapeutic targets that are emerging from translational research studies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.