Evidence map›Paper›PMID 35102726›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Accounting for lack of representation in dementia research: Generalizing KHANDLE study findings on the prevalence of cognitive impairment to the California older population.

Eleanor Hayes-Larson, Taylor M Mobley, Dan Mungas, Marissa J Seamans, M Maria Glymour, Paola Gilsanz, Charles DeCarli, Rachel A Whitmer, Elizabeth Rose Mayeda

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Lifecourse socioeconomic status and subjective cognitive decline among diverse older adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  4. Article
  5. Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Article
  7. Review
  8. The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Childhood adversity and late-life cognitive and brain health in a diverse cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Article
  14. Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Racial, Ethnic, and Geographic Diversity in Population Neuroscience.Current topics in behavioral neurosciences · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eleanor Hayes-LarsonDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Taylor M MobleyDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Dan MungasDepartment of Neurology, University of California, Davis, Sacramento, California, USA.
Marissa J SeamansDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Paola GilsanzDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Charles DeCarliDepartment of Neurology, University of California, Davis, Sacramento, California, USA.
Rachel A WhitmerAlzheimer's Disease Center, University of California, Davis, Sacramento, California, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI JOHNSON, DAVID K · 1991 to 2020
$28.3M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Audrey Peiwen Fan · 2021 to 2026
$25.2M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Lifecourse health, cerebral pathology and ethnic disparities in dementiaRF1AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GLYMOUR, MEDELLENA MARIA · 2016 to 2016
$13.1M
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementiaR01AG066132 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2019 to 2023
$2.0M
Glycemic Control and Dementia: The Role of Pharmacotherapy and Vascular ComplicationsR01AG067199 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2020 to 2024
$1.9M
Racial Disparities in Alzheimer's Disease and Related Dementias: The Role of Blood Pressure Throughout AdulthoodR00AG053410 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYEDA, ELIZABETH ROSE · 2018 to 2020
$710k
Optimizing generalizability of biomarker studies for Alzheimer’s disease and related dementias with epidemiologic toolsR56AG069126 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYEDA, ELIZABETH ROSE · 2021 to 2021
$583k
NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG072972NIA NIH HHS R00 AG053410NIA NIH HHS R01 AG052132NIA NIH HHS R01 AG066132NIA NIH HHS R01 AG067199NIA NIH HHS R56 AG069126NIA NIH HHS RF1 AG052132
6 · The paper itself

Abstract

introductionMost dementia studies are not population-representative; statistical tools can be applied to samples to obtain critically-needed population-representative estimates, but are not yet widely used.

methodsWe pooled data from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study and the California Behavioral Risk Factor Surveillance System (CA-BRFSS), a population-representative study. Using weights accounting for sociodemographic/health differences between KHANDLE and CA-BRFSS, we estimated cognitive impairment prevalence and age- and sex-adjusted racial/ethnic inequalities in California adults 65+ without prior dementia diagnosis.

resultsAfter weighting KHANDLE, the estimated cognitive impairment prevalence in California was 20.3% (95% confidence interval 17.8-23.0); unweighted prevalence was 24.8% (23.1%-26.6%). Inequalities (larger prevalences) were observed among Black and Asian groups versus whites. DISCUSSION: We used a novel statistical approach to estimate population-representative cognitive impairment prevalence and inequalities. Such statistical tools can help obtain population-representative estimates from existing studies and inform efforts to reduce racial/ethnic disparities.

Indexed as

Cognitive DysfunctionDementiaHealthy AgingAdultCaliforniaHispanic or LatinoHumansLife Change EventsPrevalencecognitive impairmentdementiageneralizabilityprevalenceracial/ethnic disparities

Identifiers

PMID35102726
PMCPMC9339583

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.