Evidence map›Paper›PMID 35106534›Full record

ArticleAmerican journal of epidemiology2022

On Variance of the Treatment Effect in the Treated When Estimated by Inverse Probability Weighting.

Sarah A Reifeis, Michael G Hudgens

Abstract read
In one paragraph

Article in American journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
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  7. Article
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  15. Article
  16. Recommendations for the use of propensity score methods in multiple sclerosis research.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sarah A Reifeis
Michael G Hudgens

Funding

Causal Inference in Infectious Disease Prevention StudiesR01AI085073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUDGENS, MICHAEL G · 2010 to 2024
$4.5M
Causal Inference in Infectious Disease Prevention StudiesR37AI085073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael G Hudgens · 2026 to 2026
$394k
NIAID NIH HHS R37 AI085073
6 · The paper itself

Abstract

In the analysis of observational studies, inverse probability weighting (IPW) is commonly used to consistently estimate the average treatment effect (ATE) or the average treatment effect in the treated (ATT). The variance of the IPW ATE estimator is often estimated by assuming that the weights are known and then using the so-called "robust" (Huber-White) sandwich estimator, which results in conservative standard errors (SEs). Here we show that using such an approach when estimating the variance of the IPW ATT estimator does not necessarily result in conservative SE estimates. That is, assuming the weights are known, the robust sandwich estimator may be either conservative or anticonservative. Thus, confidence intervals for the ATT using the robust SE estimate will not be valid, in general. Instead, stacked estimating equations which account for the weight estimation can be used to compute a consistent, closed-form variance estimator for the IPW ATT estimator. The 2 variance estimators are compared via simulation studies and in a data analysis of the association between smoking and gene expression.

Indexed as

Models, StatisticalComputer SimulationHumansProbabilityconfoundingestimating equationsexposure effectHuber-White sandwich variance estimatorinverse probability weightingobservational datatreatment effectvariance estimation

Identifiers

PMID35106534
PMCPMC9271225

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.