Evidence map›Paper›PMID 35110372›Full record

ArticleRNA (New York, N.Y.)2022

Precise gene models using long-read sequencing reveal a unique poly(A) signal in

Danielle Y Bilodeau, Ryan M Sheridan, Balu Balan, Aaron R Jex, Olivia S Rissland

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Danielle Y BilodeauDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Ryan M SheridanRNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Balu BalanPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.
Aaron R JexPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.
Olivia S RisslandDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
University of Colorado Denver · USThe University of Melbourne · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

Molecular Mechanisms of Immune ToleranceT32AI074491 · NIAID · NATIONAL JEWISH HEALTH · PI CAMBIER, JOHN C, PELANDA, ROBERTA · 2009 to 2023
$4.1M
Exploring the connections between translation and mRNA decayR35GM128680 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Olivia Selfridge Rissland · 2018 to 2026
$3.7M
NIAID NIH HHS T32 AI074491NIGMS NIH HHS R35 GM128680
6 · The paper itself

Abstract

During pre-mRNA processing, the poly(A) signal is recognized by a protein complex that ensures precise cleavage and polyadenylation of the nascent transcript. The location of this cleavage event establishes the length and sequence of the 3' UTR of an mRNA, thus determining much of its post-transcriptional fate. Using long-read sequencing, we characterize the polyadenylation signal and related sequences surrounding

Indexed as

Giardia lambliaPoly A3' Untranslated RegionsAnimalsMammalsPolyadenylationRNA, Messenger3' Untranslated RegionsPoly ARNA, Messenger3′ UTRGiardia lamblialong-read sequencingpoly(A) site

Identifiers

PMID35110372
PMCPMC9014877
OpenAlexW4225372943

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.