ArticleProceedings of the National Academy of Sciences of the United States of America2022
Mice expressing fluorescent PAR
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Dual-Targeted Inhibition of PARNanomaterials (Basel, Switzerland) · 2026Article
- Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease.Pain reports · 2026Article
- Article
- MMP1 and PRSS23 induce PARCommunications biology · 2026Article
- Epithelial TMPRSS2 impairs glucose homeostasis in obese mice by regulating ghrelin-GLP-1 receptor signaling pathway.JCI insight · 2026Article
- Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain.Biomaterials · 2026Article
- Identifying microbial protease allergens through protein language model-guided homology.Cell systems · 2026Article
- Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch.Frontiers in molecular neuroscience · 2026Article
- Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch.bioRxiv : the preprint server for biology · 2025Article
- Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Bacteroides fragilis protease activates host PARCell host & microbe · 2025Article
- Article
- The Role of PAR2 in MASLD Progression and HCC Development.International journal of molecular sciences · 2025Review
- Pain Signaling by GPCRs and RTKs.Trends in pharmacological sciences · 2025Review
- Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration.eLife · 2025Article
- Identification of a secreted protease frombioRxiv : the preprint server for biology · 2025Article
- N-terminomics profiling of naïve and inflamed murine colon reveals proteolytic signatures of legumain.Journal of cellular physiology · 2025Article
- Protease-activated Receptor 2 Promotes Crohn's Disease-Associated Colonic Fibrosis through Fibroblast Activation.Current molecular medicine · 2025Article
- Par2-mediated responses in inflammation and regeneration: choosing between repair and damage.Inflammation and regeneration · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 4 institutions in 2 countries.
Rocco LatorreDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.ORCID 0000-0003-2737-8233
Alan HegronDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Chloe J PeachDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Shavonne TengDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.ORCID 0000-0002-1045-0879
Raquel TonelloDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.ORCID 0000-0002-2175-9804
Jeffri S RetamalDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.ORCID 0000-0003-4984-4530
Rafael Klein-CloudDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.ORCID 0000-0003-0347-3543
Diana BokDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Dane D JensenDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.ORCID 0000-0001-6540-2375
Lena Gottesman-KatzDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Jeanette RientjesGene Modification Platform, Monash University, Clayton, VIC 3168, Australia.
Nicholas A VeldhuisDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0002-8902-9365
Daniel P PooleDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0002-6168-8422
Brian L SchmidtDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Charalabos H PothoulakisVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Carl RankinVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0002-8480-289X
Ying XieVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Hon Wai KoonVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0003-0618-0869
Nigel W BunnettDepartment of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010; nwb2@nyu.edu.ORCID 0000-0003-3367-0644
Neurosciences Institute · USUniversity of California, Los Angeles · USMonash University · AUNew York University · US
Funding
Targeting Endosomal Receptors for Treatment of Chronic PainR01DE029951 · NIDCR · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2020 to 2024
$4.7MProtease/PAR2/TRPV4 Axis and Oral Cancer PainR01DE026806 · NIDCR · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2018 to 2022
$3.9MEndosomal Platforms for Signaling PainR01NS102722 · NINDS · NEW YORK UNIVERSITY · PI NIGEL W BUNNETT, Brian L Schmidt · 2017 to 2026
$3.4MTrafficking-Dependent Signaling of Pain by Protease-Activated ReceptorsR01DK118971 · NIDDK · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2018 to 2021
$3.2MOrally active metabolite therapy against C. difficile infectionR21AI137663 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOON, HON WAI · 2019 to 2020
$429kNIAID NIH HHS R21 AI137663NIDCR NIH HHS R01 DE026806NIDCR NIH HHS R01 DE029951NIDDK NIH HHS R01 DK118971NINDS NIH HHS R01 NS102722
Abstract
G protein-coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and signaling of protease-activated receptor 2 (PAR
Indexed as
AnimalsArrestinsCell MembraneColonEndocytosisEndosomesFemaleFluorescent DyesGanglia, SpinalHumansInflammationMiceMice, Inbred C57BLNociceptionPainReceptor, PAR-2ArrestinsF2rl1 protein, mouseFluorescent DyesReceptor, PAR-2endocytosisinflammationproteasesreceptorssignaling
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.