ArticleNature communications2022
Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
9.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Genetic architecture of lumbar spinal stenosis.Nature communications · 2026Pooled it
- Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain.Nature communications · 2025Pooled it
- Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations.Nature communications · 2024Pooled it
- Pooled it
- A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome.Nature communications · 2022Pooled it
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- Obesity-induced intervertebral disk degeneration: pathophysiology and clinical implications.International journal of obesity (2005) · 2026Review
- Human hip osteoarthritis-associatedbioRxiv : the preprint server for biology · 2026Article
- Mitochondrial dysfunction in the pathogenesis of intervertebral disc herniation: a mitochondrial related genome-wide Mendelian randomization analysis.Journal of translational medicine · 2026Article
- Spatially Contextualized Integrative Genomics Highlights Neuronal and Glial Regulatory Programs in Low Back Pain.Journal of pain research · 2026Article
- The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications.Physiological reviews · 2025Review
- Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration.Scientific reports · 2025Article
- Electroacupuncture produces analgesic effects via cannabinoid CB1 receptor-mediated GABAergic neuronal inhibition in the rostral ventromedial medulla.Chinese medicine · 2025Article
- A multi-trait approach identified 7 novel genes for back pain.Pain reports · 2025Article
- Gene Expression Correlates with Disability and Pain Intensity in Patients with Chronic Low Back Pain and Modic Changes in a Sex-Specific Manner.International journal of molecular sciences · 2025Article
- Article
- BiallelicGenetics in medicine open · 2025Article
- Nano-Drug Delivery System Targeting the Oxidative Stress Microenvironment: A Prospective Strategy for Intervertebral Disc Degeneration Treatment.International journal of nanomedicine · 2025Review
- Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies.Frontiers in medicine · 2025Article
- Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits.Nature genetics · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
46 authors at 20 institutions in 11 countries.
Gyda BjornsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland. gyda.bjornsdottir@decode.is.ORCID http://orcid.org/0000-0002-8100-0306
Lilja StefansdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Gudmar ThorleifssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Patrick SulemdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7123-6123
Kristjan NorlanddeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Egil FerkingstaddeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-8090-7988
Asmundur OddssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Florian ZinkdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Sigrun H LunddeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Muhammad S NawazdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5576-9007
G Bragi WaltersdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5415-6487
Astros Th SkuladottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5048-0933
Sigurjon A GudjonssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Gudmundur EinarssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-1326-2339
Gisli H HalldorssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7067-9862
Valgerdur BjarnadottirLandspitali University Hospital, Reykjavik, Iceland.
Gardar SveinbjornssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Anna HelgadottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-1806-2467
Unnur StyrkarsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-8146-8278
Larus J GudmundssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Ole B PedersenDepartment of Clinical Immunology, Zealand University Hospital, Køge, Denmark.ORCID http://orcid.org/0000-0003-2312-5976
Thomas Folkmann HansenDanish Headache Center, Dept. Neurology, Rigshospitalet-Glostrup, Glostrup, Denmark.ORCID http://orcid.org/0000-0001-6703-7762
Thomas WergeDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1829-0766
Karina BanasikNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2489-2499
Anders TroelsenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0132-8182
Soren T SkouResearch Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0003-4336-7059
Lise Wegner ThørnerDepartment of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-6551-6647
Kaspar Rene NielsenDepartment of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
Susan MikkelsenDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
DBDS Genetic Consortium
GO Consortium
Ingileif JonsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-8339-150X
Aron BjornssonDepartment of Neurosurgery, Landspitali University Hospital, Reykjavik, Iceland.
Ingvar H OlafssonDepartment of Neurosurgery, Landspitali University Hospital, Reykjavik, Iceland.
Elfar UlfarssonDepartment of Neurosurgery, Landspitali University Hospital, Reykjavik, Iceland.
Josep BlondalHealth Care Institution of West Iceland, Stykkisholmur, Iceland.
Arnor VikingssonLandspitali University Hospital, Reykjavik, Iceland.
Soren BrunakNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sisse R OstrowskiDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5288-3851
Henrik UllumStatens Serum Institut, Copenhagen, Copenhagen, Denmark.
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Hreinn StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-9331-6666
Daniel F GudbjartssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Thorgeir E ThorgeirssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland. thorgeir.thorgeirsson@decode.is.
Kari StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland. kstefans@decode.is.ORCID http://orcid.org/0000-0003-1676-864X
deCODE Genetics (Iceland) · ISUniversity of Copenhagen · DKReykjavík University · ISNorwegian University of Science and Technology · NOLeiden University Medical Center · NLUniversity of Hong Kong · HKUniversity of Bristol · GBAalborg University Hospital · DKCopenhagen University Hospital · DKErasmus MC · NLGeisinger Health System · USHelmholtz Zentrum München · DEStatens Serum Institut · DKUniversity of Tartu · EEAarhus University Hospital · DKKAT General Hospital of Attica · GRAarhus University · DKAkureyri Hospital · ISBrigham and Women's Hospital · USCopenhagen Business School · DK
Funding
No grant is acknowledged in the PubMed record.
Abstract
Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (OR
Indexed as
3' Untranslated RegionsBone and BonesGenome-Wide Association StudyHumansIntervertebral DiscIntervertebral Disc DegenerationIntervertebral Disc DisplacementSodium Sulfate CotransporterSulfatesSymporters3' Untranslated RegionsSLC13A1 protein, humansodium sulfateSodium Sulfate CotransporterSulfatesSymporters
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.