SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2022
Defining and predicting radiographic knee osteoarthritis progression: a systematic review of findings from the osteoarthritis initiative.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A clinical model to predict the progression of knee osteoarthritis: data from Dryad.Journal of orthopaedic surgery and research · 2023Trial
- Effusion and synovial hyperplasia: Distinct constructs in early and late-stage knee OA.Osteoarthritis imaging · 2026Article
- Advances in heterogeneity and classification of osteoarthritis.Bone research · 2026Review
- Progression and influencing factors of knee osteoarthritis based on a multi-state Markov model: Data from OAI.Osteoarthritis and cartilage open · 2026Article
- Clinically feasible biomechanical assessment of lower limb strength and postural stability in adults aged 50-75 years with moderate knee osteoarthritis: implications for technology-enabled healthy aging.Frontiers in bioengineering and biotechnology · 2026Article
- Neuromotor frailty phenotype and fall risk in geriatrics with knee osteoarthritis: a cross-sectional analysis of physical therapy performance and psychometric outcomes.Frontiers in medicine · 2026Article
- Common intra-articular knee injections demonstrate a similar recovery trajectory over 60 months: A systematic review and meta-analysis of 15,418 participants.Journal of experimental orthopaedics · 2025Review
- Predictive validity of consensus-based MRI definition of osteoarthritis plus radiographic osteoarthritis for the progression of knee osteoarthritis: A longitudinal cohort study.Osteoarthritis and cartilage open · 2025Article
- Cartilage compositional MRI-a narrative review of technical development and clinical applications over the past three decades.Skeletal radiology · 2024Review
- The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression.Scientific reports · 2024Observational
- Externally validated models for first diagnosis and risk of progression of knee osteoarthritis.PloS one · 2022Observational
- Machine learning for clustering and classification of early knee osteoarthritis using single-leg standing kinematics.Digital healthArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
purposeThe purposes of this systematic review were to (1) identify the commonly used definitions of radiographic KOA progression, (2) summarize the important associative risk factors for disease progression based on findings from the OAI study and (3) summarize findings from radiographic KOA progression prediction modeling studies regarding the characterization of progression and outcomes.
methodsA systematic review was performed by conducting a literature search of definitions, risk factors and predictive models for radiographic KOA progression that utilized data from the OAI database. Radiographic progression was further characterized into "accelerated KOA" and "typical progression," as defined by included studies.
resultsOf 314 studies identified, 41 studies were included in the present review. Twenty-eight (28) studies analyzed risk factors associated with KOA progression, and 13 studies created or validated prediction models or risk calculators for progression. Kellgren-Lawrence (KL) grade based on radiographs was most commonly used to characterize KOA progression (50%), followed by joint space width (JSW) narrowing (32%) generally over 48 months. Risk factors with the highest odds ratios (OR) for progression included periarticular bone mineral density (OR 10.40), any knee injury within 1 year (OR 9.22) and baseline bone mineral lesions (OR 7.92). Nine prediction modeling studies utilized both clinical and structural risk factors to inform their models, and combined models outperformed purely clinical or structural models.
conclusionThe cumulative evidence suggests that combinations of structural and clinical risk factors may be able to predict radiographic KOA progression, particularly in patients with accelerated progression. Clinically relevant and feasible prediction models and risk calculators may provide valuable decision-making support when caring for patients at risk of KOA progression, although standardization in modeling and variable identification does not yet exist.
Indexed as
Identifiers
35112180What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.