ArticleeLife2022
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 106 citations in OpenAlex.
- BCG vaccination elicits protection against M. tuberculosis infection mediated by two phases of T cell immunity.JCI insight · 2026Article
- Population-level genome sequencing reveals distinctmSystems · 2026Article
- Mycobacterium tuberculosis VadK is required for the regulation of the methylcitrate cycle and virulence.EMBO reports · 2026Article
- The study of immunological markers in tuberculosis across animal models and its translation to human research.Lab animal · 2026Review
- Genetically diverse CC and DO mouse models enable comprehensive assessments of novel tuberculosis vaccines.NPJ vaccines · 2026Article
- The host immune response to Mycobacterium tuberculosis determining protection or disease progression.Nature immunology · 2026Review
- Epigenetic Reprogramming byAntibiotics (Basel, Switzerland) · 2026Review
- Integrating chemical, genetic, and feasibility assessments for anti-tubercular target validation.EMBO molecular medicine · 2026Review
- Enhanced tuberculosis control via leveraging dendritic cell-mediated Th1 responses in preventive and immunotherapeutic vaccine strategies.Journal of advanced research · 2026Article
- Review
- Population-level genome sequencing reveals distinct Mycobacterium tuberculosis intrahost mutational trajectories in simian immunodeficiency virus co-infected and antiretroviral treated non-human primates.bioRxiv : the preprint server for biology · 2026Article
- High-throughput characterization of Mycobacterium tuberculosis gene function across diverse conditions.PLoS biology · 2026Article
- High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape.Cell genomics · 2026Article
- From Plato to Pareto: Defining the shape of infection's disease space.Science advances · 2026Article
- A co-evolutionary perspective on humans andeLife · 2026Review
- Functional analysis of type VII secretion system links to host immune evasion mechanism inFrontiers in cellular and infection microbiology · 2026Review
- Characterization of a novelCurrent research in microbial sciences · 2026Article
- Lineage-Dependent IFN-γ Responses to Drug-Sensitive and Isoniazid-ResistantInfection and drug resistance · 2026Article
- Pathogenicity and virulence ofVirulence · 2025Review
- Essential redundancies fuel Mycobacterium tuberculosis adaptation to the host.PLoS pathogens · 2025Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
26 authors at 5 institutions in 2 countries.
Clare M SmithDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0003-2601-0955
Richard E BakerDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.
Megan K ProulxDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-9524-8302
Bibhuti B MishraDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-7203-1653
Jarukit E LongDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.
Sae Woong ParkDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, United States.ORCID 0000-0002-4649-4566
Ha-Na LeeDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, United States.ORCID 0000-0003-4136-0128
Michael C KiritsyDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-8364-8088
Michelle M BelleroseDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0003-0232-9953
Andrew J OliveDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0003-3441-3113
Kenan C MurphyDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-3677-2876
Kadamba PapavinasasundaramDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-7837-1344
Frederick J BoehmDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-1644-5931
Charlotte J ReamesDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-5579-5881
Rachel K MeadeDepartment of Molecular Genetics and Microbiology, Duke University, Durham, United States.ORCID 0000-0002-8322-0257
Brea K HamptonDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0001-7167-5652
Colton L LinnertzDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-2969-8193
Ginger D ShawDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-2590-4973
Pablo HockDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Timothy A BellDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0002-9546-6334
Sabine EhrtDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, United States.ORCID 0000-0002-7951-2310
Dirk SchnappingerDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, United States.
Fernando Pardo-Manuel de VillenaDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0002-5738-5795
Martin T FerrisDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-1241-6268
Thomas R IoergerDepartment of Computer Science and Engineering, Texas A&M University, College Station, United States.
Christopher M SassettiDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-6178-4329
University of Massachusetts Chan Medical School · USUniversity of North Carolina at Chapel Hill · USCornell University · USDuke University · USTexas A&M University · US
Funding
Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, HEISE, MARK T · 2012 to 2021
$36.6MSystems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2017 to 2021
$11.2MTRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5MInnate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5MGenomic Resources for the Collaborative CrossU24HG010100 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCMILLAN, LEONARD, PARDO-MANUEL DE VILLENA, FERNANDO · 2018 to 2022
$1.8MHoward Hughes Medical Institute A20-0146NHGRI NIH HHS U24 HG010100NIAID NIH HHS P01 AI132130NIAID NIH HHS T32 AI007349NIAID NIH HHS T32 AI095213NIAID NIH HHS U19 AI100625
Abstract
The outcome of an encounter with
Indexed as
Genetic Predisposition to DiseaseGenetic VariationAnimalsCollaborative Cross MiceDisease Models, AnimalGenotypeHost-Pathogen InteractionsMaleMiceMycobacterium tuberculosisPhenotypeTuberculosiscollaborative crossgeneticsgenomicshost-pathogen interactionsinfectious diseasemicrobiologymousemouse modelssystems geneticsTnSeqtuberculosis
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.