Evidence map›Paper›PMID 35113200›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2022

Minocycline as heart conditioning agent in experimental type 2 diabetes mellitus - an antibacterial drug in heart protection.

Nikola M Sobot, Tanja S Sobot, Jovana N Jeremic, Sergey B Bolevich, Stefani S Bolevich, Slobodanka Lj Mitrovic, Vladimir P Fisenko, Sofija G Inic, Andjela D Milojevic Samanovic, Marina R Rankovic and 3 more

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Nikola M SobotClinic for Cardiac Surgery, University Clinical Centre of the Republic of Srpska, Dvanaest beba st. bb, 78000, Banja Luka, Bosnia and Herzegovina.
Tanja S SobotDepartment of Physiology, University of Banja Luka, Save Mrkalja st. 14, 78000, Banja Luka, Bosnia and Herzegovina.
Jovana N JeremicDepartment of Pharmacy, University of Kragujevac, Svetozara Markovica st. 69, 34000, Kragujevac, Serbia.
Sergey B BolevichDepartment of Human Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University, Trubetskaya st. 8, Moscow, 119991, Russia.
Stefani S BolevichDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University (Sechenov University, Trubetskaya st. 8, Moscow, 119991, Russia.
Slobodanka Lj MitrovicDepartment of Pathology, University of Kragujevac, Svetozara Markovica st. 69, 34000, Kragujevac, Serbia.
Vladimir P FisenkoDepartment of Pharmacology, I.M. Sechenov First Moscow State Medical University (Sechenov University, Trubetskaya st. 8, Moscow, 119991, Russia.
Sofija G InicUniversity of Pristina With Temporary Headquarters in Kosovksa Mitrovica Anri Dinana St. Bb, 38220, Kosovska Mitrovica, Serbia.
Andjela D Milojevic SamanovicDepartment of Dentistry, University of Kragujevac, Svetozara Markovica st. 69, 34000, Kragujevac, Serbia.
Marina R RankovicDepartment of Physiology, University of Kragujevac, Svetozara Markovica st. 69, 34000, Kragujevac, Serbia.
Ivan M SrejovicDepartment of Physiology, University of Kragujevac, Svetozara Markovica st. 69, 34000, Kragujevac, Serbia.
Vladimir I ZivkovicDepartment of Physiology, University of Kragujevac, Svetozara Markovica st. 69, 34000, Kragujevac, Serbia.
Vladimir Lj JakovljevicDepartment of Human Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University, Trubetskaya st. 8, Moscow, 119991, Russia. vjakovljevic@medf.kg.ac.rs.
University of Kragujevac · RSSechenov University · RUUniversity clinical center of Republika Srpska · BAUniversity of Banja Luka · BA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases, and among them certainly myocardial infarction, remain leading cause of death worldwide. Diabetes increases risk of occurrence as well as adverse outcome of myocardial infarction. Conditioning maneuvers are the most attractive method for alleviating both the consequences of ischemia and reperfusion. Minocycline is a tetracycline derivative which exerts antioxidant, anti-inflammatory, and anti-apoptotic effects. The aim of this study was to assess the protective ability of preconditioning and postconditioning of isolated hearts from healthy and rats with experimentally induced type 2 diabetes with minocycline on functional recovery and redox status after ischemia and reperfusion. The hearts from healthy and diabetic rats were excised and retrogradely perfused according to the Langendorff technique. Using sensor in the left ventricle, the cardiodynamic parameters were recorded and in the samples of the coronary venous effluent oxidative stress biomarkers were analyzed. Minocycline was injected directly into the coronary vessels, in preconditioning 5 min before global ischemia, and in postconditioning during the first 5 min of reperfusion. Results of this study clearly show beneficial effects of minocycline applied both before ischemia and in the first minutes of reperfusion fashion in both healthy and diabetic rat hearts. The most prominent protective effect regarding oxidative stress is related to the decreased production of superoxide anion radical due postconditioning with minocycline in diabetic hearts. Cardiodynamic parameters were significantly improved in minocycline conditioned groups. Superoxide anion radical stands out as the most susceptible to changes induced by minocycline.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Myocardial Reperfusion InjuryAnimalsAnti-Bacterial AgentsHeartMinocyclineRatsAnti-Bacterial AgentsMinocyclineCardiodynamicsHeart conditioningMinocyclineOxidative stressType 2 diabetes

Identifiers

PMID35113200
OpenAlexW4210422071

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.