Evidence map›Paper›PMID 35114975›Full record

ArticleBMC endocrine disorders2022

Changes in adipokine levels and metabolic profiles following bariatric surgery.

Natalja Šebunova, Jelena Štšepetova, Tiiu Kullisaar, Kadri Suija, Anneli Rätsep, Igor Junkin, Hiie Soeorg, Margus Lember, Toomas Sillakivi, Reet Mändar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Review
  11. Observational
  12. Article
  13. Article
  14. Review
  15. Reduced risk of de novo Barrett esophagus after bariatric surgery: a national database study.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Natalja ŠebunovaDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila street 19, 50411, Tartu, Estonia.
Jelena ŠtšepetovaDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila street 19, 50411, Tartu, Estonia. jelena.stsepetova@ut.ee.
Tiiu KullisaarDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Kadri SuijaDepartment of Family Medicine, Faculty of Medicine, Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
Anneli RätsepDepartment of Family Medicine, Faculty of Medicine, Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
Igor JunkinDepartment of Family Medicine, Faculty of Medicine, Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
Hiie SoeorgDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila street 19, 50411, Tartu, Estonia.
Margus LemberDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Toomas SillakiviAbdominal Surgery Department, Tartu University Hospital, Tartu, Estonia.
Reet MändarDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila street 19, 50411, Tartu, Estonia.
University of Tartu · EECompetence Centre on Health Technologies (Estonia) · EETartu University Hospital · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients. Abdominal obesity is frequently accompanied by metabolic syndrome (MS). Adipokines are cell signaling proteins that have direct impact upon the metabolic homeostasis. The purpose of this analysis was to evaluate the effect of bariatric surgery, including laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric bypass (LRYGB) on the adipokine levels and metabolic profile as well as MS and status of type 2 diabetes (T2D).

methodsWe analyzed anthropometric parameters, blood levels of adipokines, vitamins, lipids and inflammatory markers in 30 bariatric surgery patients with obesity of class II or III 1 month before and 1 year after surgery as well as in 60 obese patients from general practice (GP) and 15 patients with normal body mass (control).

resultsThe BMI was significantly higher among patients before surgery and GP patients in comparison to control and post-surgery patients. The levels of glucose, cholesterol and LDL-cholesterol, triglyceride and hs-CRP were the highest in patients before surgery but decreased significantly after surgery, while the level of HDL-cholesterol increased after surgery. The levels of adiponectin increased and that of leptin decreased after surgery. The significant difference in the concentration of resistin was revealed between LSG and LRYGB methods. The relationship between resistin and vitamin D was also found. The patients with MS and T2D displayed significantly greater reduction in lipid markers and adipokine levels than the rest of patients.

conclusionRemarkable changes in levels of adipokines after bariatric surgery appear like increase in adiponectin and decrease in leptin levels. Significant improvement in anthropometric parameters, metabolic and inflammatory markers occurs, suggesting high potential for reduction of metabolic syndrome and risk for type 2 diabetes. We have shown for the first time ever that level of vitamin D may be involved in resistin regulation.

Indexed as

Bariatric SurgeryAdipokinesAdultAgedBiomarkersDiabetes Mellitus, Type 2FemaleHumansLipidsMaleMiddle AgedObesity, MorbidVitaminsAdipokinesBiomarkersLipidsVitaminsAdipokinesBariatric surgeryBlood indicesMetabolic syndromeWeight loss

Identifiers

PMID35114975
PMCPMC8812034
OpenAlexW4210550948

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.