ArticleNature communications2022
An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The role of chemokines and interleukins in acute lymphoblastic leukemia: a systematic review.Journal of applied biomedicine · 2024Pooled it
- Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling.Nature immunology · 2026Article
- The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy.Biomolecules · 2026Review
- The IL7 receptor and the RAG complex are required for the onset of B-cell acute lymphoblastic leukemia.Blood advances · 2025Article
- Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development.GeroScience · 2025Article
- Trajectories from single-cells to PAX5-driven leukemia reveal PAX5-MYC interplay in vivo.Leukemia · 2025Article
- CD79A and IL7R mRNA Levels in the Cerebrospinal Fluid of Adults with Acute B-Cell Lymphoblastic Leukemia: A Pilot Study.Diseases (Basel, Switzerland) · 2025Article
- Review
- Differential activation of basal and IL-7-induced PI3K/Akt/ mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia.Haematologica · 2024Article
- Concepts in B cell acute lymphoblastic leukemia pathogenesis.Journal of leukocyte biology · 2024Review
- Article
- The Role of the JAK-STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2024Review
- XBP1 promotes NRASJournal of cellular and molecular medicine · 2023Article
- Article
- Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia.Nature communications · 2023Article
- Lessons from mouse models in the impact of risk factors on the genesis of childhood B-cell leukemia.Frontiers in immunology · 2023Review
- Childhood B-Cell Preleukemia Mouse Modeling.International journal of molecular sciences · 2022Review
- miR-582 Suppresses the Proliferation of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells and Protects Them From Natural Killer Cell-Mediated Cytotoxicity.Frontiers in immunology · 2022Article
- Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.Leukemia · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 10 institutions in 5 countries.
Ifat Geron *Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Angela Maria Savino *Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Hila FishmanFelsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Noa TalFelsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
John BrownDepartment of Cancer Biology, UCL Cancer Institute, UCL, London, UK.ORCID http://orcid.org/0000-0001-7463-3503
Virginia A TuratiDepartment of Cancer Biology, UCL Cancer Institute, UCL, London, UK.ORCID http://orcid.org/0000-0002-1013-9490
Chela JamesDepartment of Cancer Biology, UCL Cancer Institute, UCL, London, UK.
Jolanda SarnoDepartment of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3488-0248
Michal Hameiri-GrossmanThe Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Yu Nee LeeFelsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Avigail ReinFelsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Hillary ManirihoFelsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Yehudit BirgerFelsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.ORCID http://orcid.org/0000-0002-3400-1306
Anna ZemlyanskyThe Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Inna MulerInstitute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Kara L DavisDepartment of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7182-2592
Victoria Marcu-MalinaCytogenetic Unit laboratory of Hematology, Chaim Sheba Medical Center Tel Hashomer, Tel Hashomer, Israel.
Nicole MattsonDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA.
Oren ParnasThe Concern Foundation Laboratories at the Lautenberg Center for immunology and Cancer Research, IMRIC, Hebrew University Faculty of Medicine, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-2714-9011
Rabea WagenerDepartment of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Ute FischerDepartment of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-2455-2489
João T BarataInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.ORCID http://orcid.org/0000-0002-4826-8976
Catriona H M JamiesonUC San Diego, Moores Cancer Center, Division of Regenerative Medicine, Department of Medicine and Sanford Stem Cell Clinical Center, Ja Jolla, CA, USA.
Markus MüschenDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA.ORCID http://orcid.org/0000-0002-6064-8613
Chun-Wei ChenDepartment of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA.ORCID http://orcid.org/0000-0002-8737-6830
Arndt BorkhardtDepartment of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-6121-4737
Ilan Richard KirschAdaptive Biotechnologies, Inc., Seattle, WA, USA.
Arnon NaglerFelsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
Tariq EnverDepartment of Cancer Biology, UCL Cancer Institute, UCL, London, UK.ORCID http://orcid.org/0000-0002-0866-6443
Shai IzraeliFelsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel. sizraeli@gmail.com.ORCID http://orcid.org/0000-0002-6938-2540
Tel Aviv University · ILCRUK Lung Cancer Centre of Excellence · GBCity of Hope · USDüsseldorf University Hospital · DESchneider Children's Medical Center · ILSheba Medical Center · ILStanford University · USAdaptive Biotechnologies (United States) · USUniversity of California San Diego · USUniversity of Lisbon · PT
Funding
Combinational Targeting the Feed-forward Epigenetic Circuitry in Mixed Lineage LeukemiaR37CA233691 · NCI · MAYO CLINIC ROCHESTER · PI CHEN, CHUN-WEI DAVID · 2019 to 2025
$2.8MRole of BAZ2A in MLL-r leukemia and therapeutic responseR01CA236626 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, CHUN-WEI DAVID · 2019 to 2023
$2.2MNCI NIH HHS R01 CA236626NCI NIH HHS R37 CA233691
Abstract
Kinase signaling fuels growth of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet its role in leukemia initiation is unclear and has not been shown in primary human hematopoietic cells. We previously described activating mutations in interleukin-7 receptor alpha (IL7RA) in poor-prognosis "ph-like" BCP-ALL. Here we show that expression of activated mutant IL7RA in human CD34
Indexed as
AnimalsAntigens, CD34Base SequenceCell DifferentiationCyclin-Dependent Kinase Inhibitor p16Gene ExpressionHumansInterleukin-7 Receptor alpha SubunitMiceMice, Inbred NODMice, KnockoutMice, SCIDPrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrecursor Cells, B-LymphoidReceptors, CytokineRNA-SeqAntigens, CD34CRLF2 protein, humanCyclin-Dependent Kinase Inhibitor p16Interleukin-7 Receptor alpha SubunitReceptors, Cytokine
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.