ArticleTranslational cancer research2019
The efficacy of dietary Spirulina as an adjunct to chemotherapy to improve immune function and reduce myelosuppression in patients with malignant tumors.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pharmacological insights intoFrontiers in pharmacology · 2025Pooled it
- Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential.Medical sciences (Basel, Switzerland) · 2026Review
- Spirulina and exercise: a two-pronged approach to mitigating oxidative stress in colorectal cancer.Molecular biology reports · 2025Review
- Spirulina as a natural shield: a comprehensive review of its protective effects against lead toxicity.Archives of toxicology · 2025Review
- Advancements of algae-involved cancer treatment.Biophysics reports · 2025Article
- Cyanobacterial Peptides in Anticancer Therapy: A Comprehensive Review of Mechanisms, Clinical Advances, and Biotechnological Innovation.Marine drugs · 2025Review
- Bilirubin metabolism in relation to cancer.Frontiers in oncology · 2025Review
- The Selective in vitro Cytotoxicity ofInternational journal of nanomedicine · 2025Article
- Comprehensive Review of the Latest Investigations of the Health-Enhancing Effects of Selected Properties ofPharmaceuticals (Basel, Switzerland) · 2024Review
- Polysaccharide extract of Spirulina sp. increases effector immune-cell killing activities against cholangiocarcinoma.PloS one · 2024Article
- Herbal supplement Spirulina stimulates inflammatory cytokine production in patients with dermatomyositisiScience · 2023Article
- Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice.BMC genomics · 2023Article
- Exploring the Benefits of Phycocyanin: From Spirulina Cultivation to Its Widespread Applications.Pharmaceuticals (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have demonstrated functional benefits of Spirulina (
methodsIn this study, cancer patients receiving four cycles of chemotherapy were randomized into control or treatment groups. The treated group consumed Spirulina for the first two cycles while the control group did not. The extent of myelosuppression and immune function were assessed after each cycle of chemotherapy, and patients were monitored for myelosuppression-related adverse events throughout the study period.
resultsIn total, 100 patients were recruited and randomized into control (n=40) or treatment (n=60) groups. The white blood cell (WBC) and neutrophil (NEU) levels were similar in both groups at baseline while they were higher in the treated group relative to controls after Cycle1 (P=0.028 for WBC; P=0.006 for NEU) and Cycle2 (P=0.023 for WBC; P=0.013 for NEU). Hemoglobin (HGB) and platelet counts (PLT) were not statistically different between the groups at baseline or after treatment. Patients in the treatment group had a significantly lower rate of severe myelosuppression (P=0.034) and less modification of the chemotherapy regimen was necessary (P=0.012). After four cycles of chemotherapy, the IgM level and number of CD8
conclusionsSpirulina reduces myelosuppression and improves immune function after chemotherapy in patients with malignant tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.