Evidence map›Paper›PMID 35118574›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2023

Transcutaneous vagus nerve stimulation attenuates autoantibody-mediated cardiovagal dysfunction and inflammation in a rabbit model of postural tachycardia syndrome.

Jielin Deng, Hongliang Li, Yankai Guo, Gege Zhang, Hayley Fischer, Stavros Stavrakis, Xichun Yu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jielin DengDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
Hongliang LiDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
Yankai GuoDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
Gege ZhangDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
Hayley FischerDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
Stavros StavrakisDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
Xichun YuDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA. xichun-yu@ouhsc.edu.ORCID http://orcid.org/0000-0001-6760-3410
University of Oklahoma Health Sciences Center · US

Funding

Autoimmune Basis for Postural Tachycardia SyndromeR01HL128393 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI YU, XICHUN · 2017 to 2024
$3.7M
NHLBI NIH HHS R01 HL128393
6 · The paper itself

Abstract

purposePrevious studies demonstrated M2 muscarinic acetylcholine receptor-activating autoantibodies (M2R-AAb) were present in some patients with postural tachycardia syndrome (POTS). This study examines how these autoantibodies might contribute to the pathophysiology of POTS, and whether low-level tragus stimulation (LLTS) can ameliorate autoantibody-mediated autonomic dysregulation in the rabbit.

methodsFive New Zealand white rabbits were immunized with a M2R second extracellular loop peptide to produce cholinomimetic M2R-AAb. Tilt test and infusion studies were performed on conscious rabbits before immunization, 6 weeks after immunization, and 8 weeks after immunization with 2-week daily LLTS treatment. Each rabbit served as its own control.

resultsCompared to preimmune state, an enhanced heart rate increase and decreased parasympathetic activity upon tilting were observed in immunized rabbits. Furthermore, these rabbits demonstrated an attenuated heart rate-slowing response to infusion of the M2R orthosteric agonist arecaidine propargyl ester (APE), suggesting an inhibitory allosteric effect of M2R-AAb. There was also a significant increase in serum inflammatory cytokines in immunized rabbits. LLTS treatment suppressed the postural tachycardia, improved the sympathovagal balance with increased acetylcholine secretion, reduced the levels of inflammatory cytokines, and reversed the attenuated heart rate response to APE in immunized rabbits. No suppression of M2R-AAb expression by LLTS was found during this short-term study period. Receptor-modulating activity of M2R-AAb produced in immunized rabbits was confirmed with in vitro bioassay.

conclusionsAutoantibody inhibition of cholinergic ligand activity may be involved in the development of cardiovagal dysfunction and inflammation associated with POTS, both of which can be improved by vagal stimulation.

Indexed as

HominidaePostural Orthostatic Tachycardia SyndromeVagus Nerve StimulationAnimalsAutoantibodiesInflammationRabbitsVagus NerveAutoantibodiesAutoantibodiesAutonomic nervous systemM2 muscarinic acetylcholine receptorPostural orthostatic tachycardia syndromeRabbitVagus nerve stimulation

Identifiers

PMID35118574
PMCPMC9349471
OpenAlexW4210274817

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.