Evidence map›Paper›PMID 35119583›Full record

ArticleMolecular and cellular biochemistry2022

Cardiac fibroblasts secrete exosome microRNA to suppress cardiomyocyte pyroptosis in myocardial ischemia/reperfusion injury.

Niannian Liu, Liang Xie, Pingxi Xiao, Xing Chen, Wenjie Kong, Qiaozhen Lou, Feng Chen, Xiang Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Niannian LiuDepartment of Cardiology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, 210031, China.
Liang XieDepartment of Cardiology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210000, Jiangsu, China.
Pingxi XiaoDepartment of Geriatrics, The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing, 211166, China.
Xing ChenDepartment of Geriatrics, The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing, 211166, China.
Wenjie KongDepartment of Cardiology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, 210031, China.
Qiaozhen LouDepartment of Cardiology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, 210031, China.
Feng ChenDepartment of Forensic Medicine, Nanjing Medical University, No. 101 Longmian Road, Jiangning District, Nanjing, 211166, Jiangsu, China. fchen@njmu.edu.cn.ORCID http://orcid.org/0000-0002-0052-0650
Xiang LuDepartment of Geriatrics, The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing, 211166, China. luxiang66@njmu.edu.cn.
Nanjing Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CNNanjing General Hospital of Nanjing Military Command · CN

Funding

national natural science foundation of china 81772020national natural science foundation of china 81922041
6 · The paper itself

Abstract

Molecular mechanisms underlying myocardial ischemia/reperfusion (MI/R) injury and effective strategies to treat MI/R injury are both in shortage. Although pyroptosis of cardiomyocytes and the protective role of cardiac fibroblasts (CFs) have been well recognized as targets to reduce MI/R injury and sudden cardiac death (SCD), the connection has not yet been established. Here, we showed that CFs protected cardiomyocytes against MI/R-induced injury through suppression of pyroptosis. A novel molecular mechanism underpinning this effect was further identified. Under hypoxia/reoxygenation condition, CFs were found to secrete exosomes, which contain increased level of microRNA-133a (miR-133a). These exosomes then delivered miR-133a into cardiomyocytes to target ELAVL1 and repressed cardiomyocyte pyroptosis. Based on this finding, we successfully developed a new strategy that used exosomes derived from CFs with overexpressed miR-133a to enhance the therapeutic outcomes for the MI/R injury. Overall, our results provide a novel molecular basis for understanding and treating MI/R injury, and our study also provides novel insight for the postmortem diagnosis of MI/R injury induced SCD by using exosome biomarker in forensic.

Indexed as

ExosomesAnimalsFibroblastsHumansMaleMiceMicroRNAsMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacRatsRats, Sprague-DawleyMicroRNAsExosomemicroRNAMyocardial ischemia/reperfusion injurySudden cardiac death

Identifiers

PMID35119583
PMCPMC8913441
OpenAlexW4210461786

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.