Evidence map›Paper›PMID 35119604›Full record

ReviewJournal of autism and developmental disorders2023

Eye Gaze in Autism Spectrum Disorder: A Review of Neural Evidence for the Eye Avoidance Hypothesis.

Nicole Stuart, Andrew Whitehouse, Romina Palermo, Ellen Bothe, Nicholas Badcock

Abstract readReview
In one paragraph

Review in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
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  9. Autism Digital Phenotyping in Preschool- and School-Age Children.Autism research : official journal of the International Society for Autism Research · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicole StuartUniversity of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia. nicoleestuart@gmail.com.ORCID http://orcid.org/0000-0001-9436-0709
Andrew WhitehouseTelethon Kids Institute, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, WA, 6009, Australia.ORCID http://orcid.org/0000-0001-8722-1575
Romina PalermoUniversity of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.ORCID http://orcid.org/0000-0002-8678-4592
Ellen BotheUniversity of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.ORCID http://orcid.org/0000-0001-5695-7010
Nicholas BadcockUniversity of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.ORCID http://orcid.org/0000-0001-6862-4694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reduced eye contact early in life may play a role in the developmental pathways that culminate in a diagnosis of autism spectrum disorder. However, there are contradictory theories regarding the neural mechanisms involved. According to the amygdala theory of autism, reduced eye contact results from a hypoactive amygdala that fails to flag eyes as salient. However, the eye avoidance hypothesis proposes the opposite-that amygdala hyperactivity causes eye avoidance. This review evaluated studies that measured the relationship between eye gaze and activity in the 'social brain' when viewing facial stimuli. Of the reviewed studies, eight of eleven supported the eye avoidance hypothesis. These results suggest eye avoidance may be used to reduce amygdala-related hyperarousal among people on the autism spectrum.

Indexed as

Autism Spectrum DisorderAutistic DisorderEyeFaceFixation, OcularHumansAmygdalaAutism spectrum disorderEye avoidanceEye gazeSocial brain

Identifiers

PMID35119604
PMCPMC10123036

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.