Evidence map›Paper›PMID 35124649›Full record

Trial reportJournal of Alzheimer's disease : JAD2022

The Effectiveness of GRADIOR: A Neuropsychological Rehabilitation Program for People with Mild Cognitive Impairment and Mild Dementia. Results of a Randomized Controlled Trial After 4 and 12 Months of Treatment.

Angie A Diaz Baquero, Manuel A Franco-Martín, Esther Parra Vidales, José Miguel Toribio-Guzmán, Yolanda Bueno-Aguado, Fernando Martínez Abad, María V Perea Bartolomé, Aysan Mahmoudi Asl, Henriëtte G van der Roest

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06515106 (Antibody-mediated LGI1 Encephalitis), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06515106 narecruitingnot on this mapstarted 2023, after this paper: background citation

Antibody-mediated LGI1 Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Chronic Phase of the Disease

TypeinterventionalSponsorFundacion Clinic per a la Recerca BiomédicaRan2023 to 2026Enrolled20ConditionsLimbic Encephalitis With LGI1 AntibodiesArmsRemote cognitive rehabilitation program
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Angie A Diaz BaqueroInstitute of Biomedical Research of Salamanca, University of Salamanca, Salamanca, Spain.
Manuel A Franco-MartínDepartment of Psychiatric, Rio Hortega University Hospital, Valladolid, Spain.
Esther Parra VidalesIBIP Center for Clinical Care in Mental Health and Aging, INTRAS Foundation, Zamora, Spain.
José Miguel Toribio-GuzmánDepartment of Research and Development, Iberico Institute for Research in Psychoscience (IBIP), INTRAS Foundation, Zamora, Spain.
Yolanda Bueno-AguadoDepartment of Gradior and Cognitive Research, INTRAS Foundation, Valladolid, Spain.
Fernando Martínez AbadUniversity Institute of Educational Sciences, University of Salamanca, Salamanca, Spain.
María V Perea BartoloméBasic Psychology, Psychobiology and Methodology Department, Salamanca University, Salamanca, Spain.
Aysan Mahmoudi AslDepartment of Research and Development, Iberico Institute for Research in Psychoscience (IBIP), INTRAS Foundation, Zamora, Spain.
Henriëtte G van der RoestDepartment on Aging, Netherlands Institute of Mental Health and Addiction (Trimbos Institute), Utrecht, The Netherlands.
Fundación INTRAS · ESUniversidad de Salamanca · ESHospital Virgen de la Concha · ESTrimbos Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComputer-based cognitive training programs have been developed with promising results on the maintenance/improvement of cognitive performance in people with dementia.

objectiveThe objective was to evaluate the effectiveness of the cognitive rehabilitation program "GRADIOR" in people with mild cognitive impairment and mild dementia.

methodThis study was a single-blind multicenter randomized clinical trial. Participants were recruited from hospitals/day centers. The experimental group (EG) and control group (CG) received computer-based cognitive training (CCT) and routine daily care, respectively. Outcome measures at T0: baseline, T1: at 4 months, T2: at 12 months were compared within and between-groups.

resultsSignificant differences or important effect sizes were detected at the intragroup and intergroup level for most variables, observing a trend of improvement and/or maintenance at 4 months by Visual Reasoning of Cambridge Cognitive Examination (CAMCOG), Digit and Arithmetic of WAIS-III, Semantic Verbal Fluency, Mini-Mental State Exam (MMSE), Trail Making Test (TMT)-A-Mistakes and at 12 months by Visual Reasoning of CAMCOG, Digit Symbol of WAIS-III, TMT-B-mistakes, Visual Memory of Rivermead Behavioural Memory Test, Lexical Verbal Fluency-P, Yesavage's Geriatric Depression Scale (GDS), TMT-A-time scales whose objective was to evaluate some executive functions and/or the memory. The CG presented a worsening trend for most of the measures towards 12 months. There was also a significant interaction between "time and group" for MMSE (F = 8.971; p = 0.03; η2 = 0.019) and the GDS (F = 3.414; p = 0.04; η2 = 0.041), as well as small effect sizes for TMT-A-time (F = 1.641; p = 0.21; η2 = 0.021) and TMT-A-mistakes (F = 0.908; p = 0.41; η2 = 0.019).

conclusionCCT with GRADIOR has been proved to benefit cognitive functions (ISRCTN:15742788).

Indexed as

Cognitive DysfunctionDementiaAgedCognitionExecutive FunctionHumansNeuropsychological TestsSingle-Blind MethodTreatment OutcomeCognitive trainingdementiamild cognitive impairmentrandomized controlled trialrehabilitation

Identifiers

PMID35124649
PMCPMC9028667
OpenAlexW4210849077

What Socratic holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.