ArticleFrontiers in human neuroscience2022
Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study.
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Tractography-based correlation of diffusion anisotropy metrics in chronic post-stroke aphasia.BMC medical imaging · 2026Article
- Differential tractography suggests a "left-to-whole" white matter degeneration pattern in aging.Brain imaging and behavior · 2026Article
- Global white matter microstructure changes induced by repetitive transcranial magnetic stimulation in cocaine use disorder: a longitudinal correlational tractography study.Brain imaging and behavior · 2026Article
- White matter microstructural changes across the menstrual cycle: a differential tractography study.Neuroradiology · 2025Article
- Late-onset GM2 gangliosidosis: magnetic resonance imaging, diffusion tensor imaging, and correlational fiber tractography differentiate Tay-Sachs and Sandhoff diseases.Journal of neurology · 2025Article
- Differential tractography: an imaging marker for tissue degeneration in neurodegenerative diseases.Brain communications · 2025Article
- Progress of radiomics research on white matter hyperintensity lesions.Frontiers in neurology · 2025Review
- Correlation of diffusion tensor tractography with obstructive sleep apnea severity.Brain and behavior · 2024Article
- Sex differences in patterns of white matter neuroplasticity after balance training in young adults.Frontiers in human neuroscience · 2024Article
- The effects of the dialysis on the white matter tracts in patients with end-stage renal disease using differential tractography study.Scientific reports · 2023Article
- Correlation of Diffusion Tensor Tractography with Restless Legs Syndrome Severity.Brain sciences · 2023Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differential tractography and correlation tractography are new tractography modalities to study neuronal changes in brain diseases, but their performances in detecting neuronal injuries are yet to be investigated in patients with mild traumatic brain injury (mTBI). Here we investigated the white matter injury in mTBI patients using differential and correlation tractography. The diffusion MRI was acquired at 33 mTBI patients and 31 health controls. 7 of the mTBI patients had one-year follow-up scans, and differential tractography was used to evaluate injured fiber bundles on these 7 patients. All subjects were evaluated using digital symbol substitution test (DSST) and trail making test A (TMT-A), and the correlation tractography was performed to explore the exact pathways related to the cognitive performance. Our results showed that differential tractography revealed neuronal changes in the corpus callosum in all 7 follow-up mTBI patients with FDR between 0.007 and 0.17. Further, the correlation tractography showed that the splenium of the corpus callosum, combined with the right superior longitudinal fasciculus and right cingulum, were correlated with DSST (FDR = 0.001669) in the acute mTBI patients. The cognitive impairment findings in the acute stage and the longitudinal findings in the corpus callosum in the chronic stage of mTBI patients suggest that differential tractography and correlation tractography are valuable tools in the diagnostic and prognostic evaluation of neuronal injuries in mTBI patients.
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