Evidence map›Paper›PMID 35126986›Full record

ArticleChemical science2022

Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation.

Madhu Nagaraj, Zahra Najarzadeh, Jonathan Pansieri, Henrik Biverstål, Greta Musteikyte, Vytautas Smirnovas, Steve Matthews, Cecilia Emanuelsson, Janne Johansson, Joel N Buxbaum and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Science advances · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

Madhu NagarajInterdisciplinary Nanoscience Center (iNANO), Aarhus University Gustav Wieds Vej 14 DK - 8000 Aarhus C Denmark dao@inano.au.dk.
Zahra NajarzadehInterdisciplinary Nanoscience Center (iNANO), Aarhus University Gustav Wieds Vej 14 DK - 8000 Aarhus C Denmark dao@inano.au.dk.
Jonathan PansieriDepartment of Medical Biochemistry and Biophysics, Umeå University 90187 Umeå Sweden.
Henrik BiverstålDepartment of Biosciences and Nutrition, Neo, Karolinska Institutet S - 141 83 Huddinge Sweden.
Greta MusteikyteInstitute of Biotechnology, Life Sciences Center, Vilnius University Vilnius Lithuania.ORCID https://orcid.org/0000-0002-4585-5091
Vytautas SmirnovasInstitute of Biotechnology, Life Sciences Center, Vilnius University Vilnius Lithuania.
Steve MatthewsDepartment of Life Sciences, Imperial College London, South Kensington Campus London SW72AZ UK.
Cecilia EmanuelssonDepartment of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University PO Box 124 SE-22100 Lund Sweden.
Janne JohanssonDepartment of Biosciences and Nutrition, Neo, Karolinska Institutet S - 141 83 Huddinge Sweden.
Joel N BuxbaumThe Scripps Research Institute 10550 North Torrey Pines Road La Jolla CA 92037 USA.ORCID https://orcid.org/0000-0001-5216-6414
Ludmilla Morozova-RocheDepartment of Medical Biochemistry and Biophysics, Umeå University 90187 Umeå Sweden.ORCID https://orcid.org/0000-0001-5886-2023
Daniel E OtzenInterdisciplinary Nanoscience Center (iNANO), Aarhus University Gustav Wieds Vej 14 DK - 8000 Aarhus C Denmark dao@inano.au.dk.ORCID https://orcid.org/0000-0002-2918-8989
Aarhus University · DKKarolinska Institutet · SEUmeå University · SEVilnius University · LTImperial College London · GBLund University · SEScripps Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlike misfolding in neurodegenerative diseases, aggregation of functional amyloids involved in bacterial biofilm,

Identifiers

PMID35126986
PMCPMC8729806
OpenAlexW4200539082

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.