ArticleAmerican journal of physiology. Renal physiology2022
Kidney-specific KO of the circadian clock protein PER1 alters renal Na
Open access · greenAbstract read
In one paragraph
Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
- Loss of the Circadian Clock Protein Period 1 Mediates Sex-Dependent Increase in Arterial Stiffness and Hypertrophic Remodeling in Mice.Journal of the American Heart Association · 2026Article
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity.Function (Oxford, England) · 2026Review
- Circadian rhythms in glomerular filtration govern natriuresis and diuretic responsiveness.Frontiers in physiology · 2026Article
- Tuned by time: the role of circadian rhythms in metabolic energy sensing and chronotherapy.Annals of medicine · 2025Review
- Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC.Communications biology · 2025Article
- Perturbation of the circadian clock in chronic diseases involving organ fibrosis.The Journal of clinical investigation · 2025Review
- Endothelin-1 signaling in the kidney: recent advances and remaining gaps.American journal of physiology. Renal physiology · 2025Review
- Disruption of circadian rhythm as a potential pathogenesis of nocturia.Nature reviews. Urology · 2025Review
- Research progress on the role and mechanism of circadian clock geneFrontiers in immunology · 2025Review
- A comparative transcriptomics analysis of mammalian and non-mammalian acute kidney injury (AKI) models.Frontiers in cell and developmental biology · 2025Article
- Sex differences in the adrenal circadian clock: a role for BMAL1 in the regulation of urinary aldosterone excretion and renal electrolyte balance in mice.American journal of physiology. Renal physiology · 2025Article
- Comprehensive analysis of the endothelin system in the kidneys of mice, rats, and humans.Bioscience reports · 2024Article
- Circadian rhythm disruption and endocrine-related tumors.World journal of clinical oncology · 2024Review
- Recent advances in understanding the kidney circadian clock mechanism.American journal of physiology. Renal physiology · 2024Review
- Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024Review
- Meal timing and its role in obesity and associated diseases.Frontiers in endocrinology · 2024Review
- Aldosterone Antagonism Is More Effective at Reducing Blood Pressure and Excessive Renal ENaC Activity in AngII-Infused Female Rats Than in Males.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Circadian gene expression in mouse renal proximal tubule.American journal of physiology. Renal physiology · 2023Article
- The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.Canadian journal of physiology and pharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Lauren G DoumaDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.ORCID 0000-0001-8216-9253
Hannah M CostelloDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
G Ryan CrislipDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Kit-Yan ChengDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
I Jeanette LynchDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida.
Alexandria JuffreDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Dominique BarralDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida.
Sarah MastenDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida.
Emilio RoigDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida.
Kevin BeguiristainDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida.
Wendy LiDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida.
Phillip BratanatawiraDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida.
Charles S WingoDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida.
Michelle L GumzDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.ORCID 0000-0002-1342-0878
University of Florida · US
Funding
REnal TrAIning & reteNtion (RETAIN) ProgramT32DK104721 · NIDDK · UNIVERSITY OF FLORIDA · PI SEGAL, MARK S., WOOD, CHARLES E · 2015 to 2019
$1.6MPer1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5MBlood Pressure Regulation by the Circadian Clock Protein Per1R03DK098460 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2013 to 2014
$149kThe Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation in Male and Female MiceF32DK121424 · NIDDK · UNIVERSITY OF FLORIDA · PI CRISLIP, GENE RYAN · 2019 to 2021
$130kNIDDK NIH HHS F32 DK121424NIDDK NIH HHS R01 DK109570NIDDK NIH HHS R03 DK098460NIDDK NIH HHS T32 DK104721
Abstract
PERIOD 1 (PER1) is a circadian clock transcription factor that is regulated by aldosterone, a hormone that increases blood volume and Na
Indexed as
AldosteroneCircadian ClocksHypertensionKidneyPeriod Circadian ProteinsAnimalsCadherinsGene ExpressionMaleMiceMice, KnockoutSodiumSodium Chloride, DietaryAldosteroneCadherinsPer1 protein, mousePeriod Circadian ProteinsSodiumSodium Chloride, Dietarycircadian rhythmhomeostasissaltsodium
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.